EIF3E_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIF3E_DROME
• UniProt AC: O77410
• Protein Name: Eukaryotic translation initiation factor 3 subunit E {ECO:0000255|HAMAP-Rule:MF_03004}
• Gene Name: eIF3e {ECO:0000255|HAMAP-Rule:MF_03004}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 435
• Subcellular Localization: Cytoplasm . Microsome . Endoplasmic reticulum . Uniformly distributed in interphase and mitotic cells.
• Protein Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. [PubMed: 18493598 In addition to its role in the eIF-3 complex, also functions in protein ubiquitination and degradation]
• Protein Sequence: MANFDLTRINCQFLDRHLTFPLLEFLCGKEIYNQQELLEYILETVNKTNMIDYTMDTRKRLNLSQEMPEELVQRKAEVLATLKQLQNEVAPIMKATDILKNGESMKDSKTFVNALQKDYNFKVEHLESAYKLAKYLYECGNYQESTSYLYFCLIVMSPNDKNYLNVLWGKLAAEILTLNWNTALEDLTRLRDYIDNANFSTIQALQQRTWLIHWSVLVFFNHPKGRDLIIEMFLYKPLYLNAIQTMCPHIMRYLATAVVINRTRRNALKDLIKVIQQESYTYRDPITEFLECLYVNFDFEGARLKLHECQTVILNDFFIVACLNEFVEDARLMIFETFCRIHQCITISMLADKLNMKPNEAECWIVNLIRNARLNAKIDSKLGHVVMGTQPLSPYQQLVEKIDSLSMRSEHLAGLIERKSKQKQNQESADSWKYY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
104	Phosphorylation	DILKNGESMKDSKTF HHHHCCCCCCCCHHH	32.31	22817900
269	Acetylation	RTRRNALKDLIKVIQ HHHHHHHHHHHHHHH	48.34	21791702
393	Phosphorylation	VMGTQPLSPYQQLVE CCCCCCCCHHHHHHH	28.39	19429919
395	Phosphorylation	GTQPLSPYQQLVEKI CCCCCCHHHHHHHHH	12.91	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIF3E_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIF3E_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIF3E_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EIF3C_DROME	eIF3-S8	physical	22036573
EIF3L_DROME	CG5642	physical	22036573
EIF3M_DROME	Tango7	physical	22036573
EI3F1_DROME	CG9769	physical	22036573
EIF3K_DROME	CG10306	physical	22036573
EIF3B_DROME	eIF3-S9	physical	22036573
EIF3A_DROME	eIF3-S10	physical	22036573
EI3GA_DROME	CG8636	physical	22036573
EI3D1_DROME	eIF-3p66	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.