EGR1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EGR1_MOUSE
• UniProt AC: P08046
• Protein Name: Early growth response protein 1
• Gene Name: Egr1
• Organism: Mus musculus (Mouse).
• Sequence Length: 533
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Transcriptional regulator. [PubMed: 8336701]
• Protein Sequence: MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGTPEGSGGNSSSSTSSGGGGGGGSNSGSSAFNPQGEPSEQPYEHLTTESFSDIALNNEKAMVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPTSSSSAPSPAASSSSSASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPATKGGFQVPMIPDYLFPQQQGDLSLGTPDQKPFQGLENRTQQPSLTPLSTIKAFATQSGSQDLKALNTTYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASPAASSLSSYPSPVATSYPSPATTSFPSPVPTSYSSPGSSTYPSPAHSGFPSPSVATTFASVPPAFPTQVSSFPSAGVSSSFSTSTGLSDMTATFSPRTIEIC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	KAEMQLMSPLQISDP HHHHHHCCCCCCCCC	30.93	25338131
26	Phosphorylation	PFGSFPHSPTMDNYP CCCCCCCCCCCCCCC	23.46	25338131
117	O-linked_Glycosylation	EKAMVETSYPSQTTR CCCCEECCCCCCCCC	22.88	21606357

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
26	S	Phosphorylation	Kinase	ERK1	Q63844	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EGR1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EGR1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
G3BP1_MOUSE	G3bp1	physical	18627790
EGR1_MOUSE	Egr1	physical	20211142
NAB2_MOUSE	Nab2	physical	20211142
SP1_MOUSE	Sp1	physical	12569082

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.