NAB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAB2_MOUSE
• UniProt AC: Q61127
• Protein Name: NGFI-A-binding protein 2
• Gene Name: Nab2
• Organism: Mus musculus (Mouse).
• Sequence Length: 525
• Subcellular Localization: Nucleus. Isoform 2 is not localized to the nucleus.
• Protein Description: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability..
• Protein Sequence: MHRAPSPTAEQPPGRGDNTRRTPQPRFKASAPAMALPRTLGELQLYRVLQRANLLSYYETFIQQGGDDVQQLCEAGEEEFLEIMALVGMATKPLHVRRLQKALREWATNPGLFSQPVPAVPVSSIPLFKISETAGTRKGSMSNGHGSPGEKAGSARSFSPKSPLELGEKLSPLPGGPGAGDPRIWPGQSTPESDVGAGGEEEAGSPPFSPPAGGGVSEGPGVGGVAAGGAGGGPDRLEPEMVRMVVESVERIFRSFPRGDTGEIASLLKLNKKLARSVGHIFEMDDHDAQKEEEIRKYSVIYGRLDSKRREGKQLSLHELTINEAAAQFCMRDNTLLLRRVELFSLSRQVARESTYLSSLKGSRLHSEELGGPPLKKLKQEVGEQSHNEIQQPPPGPESYAPPYRPSLEEDSASLSGESLDGHLQAVGSCPRLTPPPADLPLALPAHGLWSRHILQQTLMDEGLRLARLVSHDRVGRLSPCVPAKPPLAEFEEGLLDRCPAPGPHPALVEGRRSSVKVEAEASRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MHRAPSPTAEQPP --CCCCCCCCCCCCC	33.62	26824392
8	Phosphorylation	MHRAPSPTAEQPPGR CCCCCCCCCCCCCCC	47.35	24899341
19	Phosphorylation	PPGRGDNTRRTPQPR CCCCCCCCCCCCCCC	26.69	25777480
136	Phosphorylation	KISETAGTRKGSMSN EEECCCCCCCCCCCC	27.09	25338131
140	Phosphorylation	TAGTRKGSMSNGHGS CCCCCCCCCCCCCCC	23.28	23684622
142	Phosphorylation	GTRKGSMSNGHGSPG CCCCCCCCCCCCCCC	41.16	23375375
147	Phosphorylation	SMSNGHGSPGEKAGS CCCCCCCCCCCCCCC	24.85	27087446
154	Phosphorylation	SPGEKAGSARSFSPK CCCCCCCCCCCCCCC	25.93	23375375
157	Phosphorylation	EKAGSARSFSPKSPL CCCCCCCCCCCCCCC	29.77	27087446
159	Phosphorylation	AGSARSFSPKSPLEL CCCCCCCCCCCCCHH	32.44	27087446
162	Phosphorylation	ARSFSPKSPLELGEK CCCCCCCCCCHHCCC	37.79	27087446
171	Phosphorylation	LELGEKLSPLPGGPG CHHCCCCCCCCCCCC	35.14	24925903
189	Phosphorylation	PRIWPGQSTPESDVG CCCCCCCCCCHHHCC	52.42	25338131
190	Phosphorylation	RIWPGQSTPESDVGA CCCCCCCCCHHHCCC	24.16	26370283
193	Phosphorylation	PGQSTPESDVGAGGE CCCCCCHHHCCCCCC	38.51	26370283
205	Phosphorylation	GGEEEAGSPPFSPPA CCCCCCCCCCCCCCC	36.13	26370283
209	Phosphorylation	EAGSPPFSPPAGGGV CCCCCCCCCCCCCCC	35.43	24453211
217	Phosphorylation	PPAGGGVSEGPGVGG CCCCCCCCCCCCCCC	39.86	23649490
255	Phosphorylation	SVERIFRSFPRGDTG HHHHHHHHCCCCCHH	28.93	22871156
261	Phosphorylation	RSFPRGDTGEIASLL HHCCCCCHHHHHHHH	39.27	22871156
354	Phosphorylation	SRQVARESTYLSSLK HHHHHHHHHHHHCCC	19.46	29514104
355	Phosphorylation	RQVARESTYLSSLKG HHHHHHHHHHHCCCC	24.59	29514104
358	Phosphorylation	ARESTYLSSLKGSRL HHHHHHHHCCCCCCC	24.18	29176673
359	Phosphorylation	RESTYLSSLKGSRLH HHHHHHHCCCCCCCC	31.35	27180971
367	Phosphorylation	LKGSRLHSEELGGPP CCCCCCCHHHHCCCC	37.04	26824392
434	Phosphorylation	VGSCPRLTPPPADLP CCCCCCCCCCCCCCC	34.72	26824392
451	Phosphorylation	LPAHGLWSRHILQQT CCCCCHHHHHHHHHH	21.01	25777480
471	Phosphorylation	LRLARLVSHDRVGRL HHHHHHHHCCCCCCC	25.02	25367039
479	Phosphorylation	HDRVGRLSPCVPAKP CCCCCCCCCCCCCCC	18.20	26824392
514	Phosphorylation	ALVEGRRSSVKVEAE HHHCCCCCCCCCCHH	37.82	25619855
515	Phosphorylation	LVEGRRSSVKVEAEA HHCCCCCCCCCCHHH	24.93	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAB2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHD4_MOUSE	Chd4	physical	16574654

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-171, AND MASSSPECTROMETRY.
PubMed: 19131326

"A differential phosphoproteomic analysis of retinoic acid-treated P19cells.";
Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.;
J. Proteome Res. 6:3174-3186(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-159; SER-162 ANDSER-171, AND MASS SPECTROMETRY.
PubMed: 17622165