EB1C_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EB1C_ARATH
• UniProt AC: Q9FGQ6
• Protein Name: Microtubule-associated protein RP/EB family member 1C
• Gene Name: EB1C
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 329
• Subcellular Localization: Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, phragmoplast. During mitosis, accumulates in the prophase nucleus, and after the nuclear envelope disintegration is associated with whole spindle microtubules, plus end of microtubul
• Protein Description: Plant-specific EB1 subtype that functions preferentially at early stages of plant mitosis by regulating spindle positioning and chromosome segregation. Accumulates in the prophase nucleus and is required to maintain spindle bipolarity during premetaphase and/or metaphase and for efficient segregation of chromosomes at anaphase. May play a role in the dynamics of microtubule network in elongating pollen tubes..
• Protein Sequence: MATNIGMMDSAYFVGRSEILAWINSTLQLNLSKVEEACSGAVHCQLMDSVHPGTVPMHKVNFDAKSEYEMIQNYKVLQDVFNKLKITKHIEVSKLVKGRPLDNLEFMQWMKKYCDSVNGGQHNYHALERREASKGGKEATKRAAATQQSGKSSSSSAPPRPSSSNGTRKHEPQSNNTGTHHSSTGNHHHSSKPSAKQSKPVPAYDEKITELKLYIDSLEKERDFYFSKLRDVEILCQNPDTEHLPLVGSIKRILYAADGEDVGAAETQTLSPIAEGSEERRNSVTESQKRKLIVNLDVDVAAITTLSPRQRLSDASDVKCSGSSPLLTC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
167	Phosphorylation	RPSSSNGTRKHEPQS CCCCCCCCCCCCCCC		25561503
255	Phosphorylation	GSIKRILYAADGEDV HHHHEEEEECCCCCC		23776212
267	Phosphorylation	EDVGAAETQTLSPIA CCCCCCCCCCCCCCC		23776212
269	Phosphorylation	VGAAETQTLSPIAEG CCCCCCCCCCCCCCC		23776212
271	Phosphorylation	AAETQTLSPIAEGSE CCCCCCCCCCCCCCH		23776212
277	Phosphorylation	LSPIAEGSEERRNSV CCCCCCCCHHHHHCC		23776212
283	Phosphorylation	GSEERRNSVTESQKR CCHHHHHCCCHHHHH		25561503
285	Phosphorylation	EERRNSVTESQKRKL HHHHHCCCHHHHHHE		25561503
321	Phosphorylation	DASDVKCSGSSPLLT CHHCCCCCCCCCCCC		25561503
323	Phosphorylation	SDVKCSGSSPLLTC- HCCCCCCCCCCCCC-		25561503
324	Phosphorylation	DVKCSGSSPLLTC-- CCCCCCCCCCCCC--		25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EB1C_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EB1C_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EB1C_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EB1C_ARATH	EB1C	physical	20067996
MPK6_ARATH	MPK6	physical	26061286

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.