DRAM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DRAM1_HUMAN
• UniProt AC: Q8N682
• Protein Name: DNA damage-regulated autophagy modulator protein 1
• Gene Name: DRAM1
• Organism: Homo sapiens (Human).
• Sequence Length: 238
• Subcellular Localization: Lysosome membrane ; Multi-pass membrane protein .
• Protein Description: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy..
• Protein Sequence: MLCFLRGMAFVPFLLVTWSSAAFIISYVVAVLSGHVNPFLPYISDTGTTPPESGIFGFMINFSAFLGAATMYTRYKIVQKQNQTCYFSTPVFNLVSLVLGLVGCFGMGIVANFQELAVPVVHDGGALLAFVCGVVYTLLQSIISYKSCPQWNSLSTCHIRMVISAVSCAAVIPMIVCASLISITKLEWNPREKDYVYHVVSAICEWTVAFGFIFYFLTFIQDFQSVTLRISTEINGDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
164	Phosphorylation	CHIRMVISAVSCAAV HHHHHHHHHHHHHHH	15.94	-
167	Phosphorylation	RMVISAVSCAAVIPM HHHHHHHHHHHHHHH	9.58	-
182	Phosphorylation	IVCASLISITKLEWN HHHHHHHHHHCCCCC	29.51	24719451
225	Phosphorylation	TFIQDFQSVTLRIST HHHHHHHHCHHEEEC	19.64	24719451
227	Phosphorylation	IQDFQSVTLRISTEI HHHHHHCHHEEECEE	18.63	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DRAM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DRAM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DRAM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
CA021_HUMAN	C1orf21	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.