DOK1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOK1_RAT
• UniProt AC: Q4QQV2
• Protein Name: Docking protein 1
• Gene Name: Dok1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 480
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity)..
• Protein Sequence: MDGALMEGPLFLQSQRFGTKRWKKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGGSRRLDCKMIRLAECVSVVPVTVESPPEPGASAFRLDTAQRSHLLAADAASSTAWVQILCRTAFPKGGWALAQTENPPKFSALEMLENSLYSPTWEGSQFWVTSQKTEASERCGLQGSYVLRVEAEKLTLLTLGAQSQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVEAAIQQQKAQGKVGQGQDITRTDSHDGETEGKMAPTPVPQEPLGSPPALYAEPLDSLRIPPGPSQDSLYSDPLGSTPAGAGEGVQRKKPLYWDLYGHVQQQLLKTKLIDSKEDPIYDEPEGLAPAPLRGLYDLPQEPKDAWWCQARLKEEGYELPYNPATDDYAVPPPRSSKPTPAPKPQGLILPESGTTAGSGSKGSDTALYSQVQKSGTPGRWDCGLSRVGNDRVGVKSEGST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDGALMEG -------CCCCCCCC	10.94	-
48	Phosphorylation	EFFDHKGSSSGGGRG EEECCCCCCCCCCCC	26.57	-
265	Phosphorylation	VGQGQDITRTDSHDG CCCCCCCCCCCCCCC	35.49	25575281
267	Phosphorylation	QGQDITRTDSHDGET CCCCCCCCCCCCCCC	32.95	25575281
269	Phosphorylation	QDITRTDSHDGETEG CCCCCCCCCCCCCCC	23.90	22668510
274	Phosphorylation	TDSHDGETEGKMAPT CCCCCCCCCCEECCC	56.41	25575281
290	Phosphorylation	VPQEPLGSPPALYAE CCCCCCCCCCCEECC	35.08	22108457
295	Phosphorylation	LGSPPALYAEPLDSL CCCCCCEECCCCCCC	15.83	-
336	Phosphorylation	VQRKKPLYWDLYGHV CCCCCCCHHHHHHHH	12.85	-
340	Phosphorylation	KPLYWDLYGHVQQQL CCCHHHHHHHHHHHH	11.60	-
361	Phosphorylation	DSKEDPIYDEPEGLA CCCCCCCCCCCCCCC	21.46	25532521
376	Phosphorylation	PAPLRGLYDLPQEPK CCCCCCCCCCCCCCC	20.47	30181290
397	Phosphorylation	ARLKEEGYELPYNPA EEHHHCCCCCCCCCC	19.99	21940666
408	Phosphorylation	YNPATDDYAVPPPRS CCCCCCCCCCCCCCC	16.59	21940666
415	Phosphorylation	YAVPPPRSSKPTPAP CCCCCCCCCCCCCCC	48.78	-
448	Phosphorylation	KGSDTALYSQVQKSG CCCCCHHHHHHHHCC	8.45	25532521
449	Phosphorylation	GSDTALYSQVQKSGT CCCCHHHHHHHHCCC	25.40	30181290

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
361	Y	Phosphorylation	Kinase	INSR	P15127	Uniprot
397	Y	Phosphorylation	Kinase	INSR	P15127	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOK1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOK1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SHIP1_RAT	Inpp5d	physical	11970986
RASA1_RAT	Rasa1	physical	11970986
RASA1_RAT	Rasa1	physical	12008030
SHC1_RAT	Shc1	physical	12008030
SHIP1_RAT	Inpp5d	physical	12008030

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.