DACT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DACT2_HUMAN
• UniProt AC: Q5SW24
• Protein Name: Dapper homolog 2
• Gene Name: DACT2
• Organism: Homo sapiens (Human).
• Sequence Length: 774
• Protein Description: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity)..
• Protein Sequence: MWTPGGPPGSAGWDRRRLGARLRAAFAGLQELQGLRATQQERVRGALALQPPPAPAAPCGPHGLHGPEQQLEAALAALQEQLSRLRQQDIGLKTHLDQLDLQISKLQLDVGTASGEALDSDSRPSSGFYEMSDGGSCSLSTSCASVCSDHISPSLGSLLPVAQAHKARPSMGDWRPRSVDETTVPAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASADAELLGLLCQGVDIPLHVPDPKYRQDLVSQGGREVYPYPSPLHAVALQSPLFVLTKETPQRGGPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPSPASGHFAHPSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLLDRPEGAHAAPQPSLEWDPAHWPTGRGGLQRRPALAWEAPGRSCSESTLYPMPVLVPLAVAPQESHRTSAQALFPFEASLLTSVARRKHRRWQSTVEISARARLASCPESNLGPPRPVARRAGGPLARGRPSLVRQDAYTRSDSEPSKHSAECDPRFPSVIPETSEGESSDHTTNRFGDRESSSSDEEGGAQSRDCDLALGYVAAGHAELAWTQEAPVSSGPLLSPVPKLCRIKASKALKKKIRRFQPTALKVMTMV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	TPGGPPGSAGWDRRR CCCCCCCCCCCHHHH	29.40	-
218	Phosphorylation	TFWPRPVSTGDLDRA CCCCCCCCCCCHHHC	29.38	-
230	Phosphorylation	DRALPADTGLQKASA HHCCCCCCCCHHHHH	41.73	-
372	Phosphorylation	PQRQGGWSTDGGGRL CCCCCCEECCCCCCE	21.64	23403867
373	Phosphorylation	QRQGGWSTDGGGRLL CCCCCEECCCCCCEE	31.96	23403867
408	Phosphorylation	GGPQQQGYMPLEGPQ CCCCCCCCCCCCCCC	7.39	27642862
462	Phosphorylation	YGRGNIISPSRMLDK HCCCCCCCHHHHCCC	17.02	23532336
493	Acetylation	SLKMGPPKSKAEKIK HHCCCCCHHHHHHHH	68.66	19819075
495	Acetylation	KMGPPKSKAEKIKRS CCCCCHHHHHHHHCC	67.69	19819081
661	Phosphorylation	DAYTRSDSEPSKHSA CCCCCCCCCCCCCCC	53.29	30576142
664	Phosphorylation	TRSDSEPSKHSAECD CCCCCCCCCCCCCCC	38.66	25954137
667	Phosphorylation	DSEPSKHSAECDPRF CCCCCCCCCCCCCCC	29.51	25954137
766	Phosphorylation	KIRRFQPTALKVMTM HHHHHCCCHHHHHHC	33.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DACT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DACT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DACT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCC2D_HUMAN	CAMK2D	physical	26186194
KCC2G_HUMAN	CAMK2G	physical	26186194
VHL_HUMAN	VHL	physical	25825496

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.