CXCR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXCR1_HUMAN
• UniProt AC: P25024
• Protein Name: C-X-C chemokine receptor type 1
• Gene Name: CXCR1
• Organism: Homo sapiens (Human).
• Sequence Length: 350
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity..
• Protein Sequence: MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	N-linked_Glycosylation	-----MSNITDPQMW -----CCCCCCCCCC	39.62	UniProtKB CARBOHYD
16	N-linked_Glycosylation	MWDFDDLNFTGMPPA CCCCCCCCCCCCCCC	39.15	UniProtKB CARBOHYD
27	Phosphorylation	MPPADEDYSPCMLET CCCCCCCCCCCCCCC	16.68	23879269
28	Phosphorylation	PPADEDYSPCMLETE CCCCCCCCCCCCCCC	24.76	23879269
67	Phosphorylation	VMLVILYSRVGRSVT HHHHHHHHCCCCCHH	19.62	24719451
114	Phosphorylation	TFLCKVVSLLKEVNF HHHHHHHHHHHHCCC	30.85	24719451
122	Phosphorylation	LLKEVNFYSGILLLA HHHHCCCCCHHHHHH	10.77	22210691
136	Phosphorylation	ACISVDRYLAIVHAT HHHCHHHHHHHHHHH	8.95	22210691
147	Phosphorylation	VHATRTLTQKRHLVK HHHHCHHHCHHHHHH	31.28	22210691
225	Phosphorylation	MLFCYGFTLRTLFKA HHHHHHHHHHHHHHH	15.80	24719451
279	Methylation	VIQESCERRNNIGRA HHHHHHHHHCCHHHH	51.45	12018679
280	Methylation	IQESCERRNNIGRAL HHHHHHHHCCHHHHH	20.46	12018689
338	Phosphorylation	LARHRVTSYTSSSVN HHHCCCCCCCCCCCC	24.45	26434552
343	Phosphorylation	VTSYTSSSVNVSSNL CCCCCCCCCCCCCCC	19.92	26434552

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CXCR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXCR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
279	Methylation	276 (3)	S ⇒ T	rs2234671	Idiopathic intracranial hypertension	29608535
280	Methylation	276 (4)	S ⇒ T	rs2234671	Idiopathic intracranial hypertension	29608535

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNAI2_HUMAN	GNAI2	physical	8903513
GNAI2_HUMAN	GNAI2	physical	8662698
UBE2C_HUMAN	UBE2C	physical	21988832
TBA1A_HUMAN	TUBA1A	physical	21988832
PDC6I_HUMAN	PDCD6IP	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.