CPL1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPL1_ARATH
• UniProt AC: Q5YDB6
• Protein Name: RNA polymerase II C-terminal domain phosphatase-like 1 {ECO:0000305}
• Gene Name: CPL1 {ECO:0000303|PubMed:15388846}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 967
• Subcellular Localization: Nucleus . Nucleus speckle .
• Protein Description: Processively dephosphorylates 'Ser-5' but not 'Ser-2' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II. Together with CPL2, required for male gametes fertility. Multifunctional regulator that modulates plant growth, stress, and phytohormones responses. Negative regulator of stress gene transcription involved in abscisic acid (ABA) mediated and jasmonic acid (JA) mediated signaling pathways, NaCl, osmotic stress, wounding, and cold resistance. Regulates negatively the expression of jasmonic acid (JA) biosynthetic genes in response to wounding. [PubMed: 11874572]
• Protein Sequence: MYSNNRVEVFHGDGRLGELEIYPSRELNQQQDDVMKQRKKKQREVMELAKMGIRISHFSQSGERCPPLAILTTISSCGLCFKLEASPSPAQESLSLFYSSCLRDNKTAVMLLGGEELHLVAMYSENIKNDRPCFWAFSVAPGIYDSCLVMLNLRCLGIVFDLDETLVVANTMRSFEDKIDGFQRRINNEMDPQRLAVIVAEMKRYQDDKNLLKQYIESDQVVENGEVIKVQSEIVPALSDNHQPLVRPLIRLQEKNIILTRINPMIRDTSVLVRMRPSWEELRSYLTAKGRKRFEVYVCTMAERDYALEMWRLLDPEGNLINTNDLLARIVCVKSGFKKSLFNVFLDGTCHPKMALVIDDRLKVWDEKDQPRVHVVPAFAPYYSPQAEAAATPVLCVARNVACGVRGGFFRDFDDSLLPRIAEISYENDAEDIPSPPDVSHYLVSEDDTSGLNGNKDPLSFDGMADTEVERRLKEAISASSAVLPAANIDPRIAAPVQFPMASASSVSVPVPVQVVQQAIQPSAMAFPSIPFQQPQQPTSIAKHLVPSEPSLQSSPAREEGEVPESELDPDTRRRLLILQHGQDTRDPAPSEPSFPQRPPVQAPPSHVQSRNGWFPVEEEMDPAQIRRAVSKEYPLDSEMIHMEKHRPRHPSFFSKIDNSTQSDRMLHENRRPPKESLRRDEQLRSNNNLPDSHPFYGEDASWNQSSSRNSDLDFLPERSVSATETSADVLHGIAIKCGAKVEYKPSLVSSTDLRFSVEAWLSNQKIGEGIGKSRREALHKAAEASIQNLADGYMRANGDPGPSHRDATPFTNENISMGNANALNNQPFARDETALPVSSRPTDPRLEGSMRHTGSITALRELCASEGLEMAFQSQRQLPSDMVHRDELHAQVEIDGRVVGEGVGSTWDEARMQAAERALSSVRSMLGQPLHKRQGSPRSFGGMSNKRLKPDFQRSLQRMPSSGRYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
269	Phosphorylation	INPMIRDTSVLVRMR ECHHHCCCEEEEEEC	15.75	24894044
270	Phosphorylation	NPMIRDTSVLVRMRP CHHHCCCEEEEEECC	20.10	24894044
278	Phosphorylation	VLVRMRPSWEELRSY EEEEECCCHHHHHHH	36.43	24894044
506	Phosphorylation	FPMASASSVSVPVPV CCCCCCCCCCCCCCH	20.37	28011693
508	Phosphorylation	MASASSVSVPVPVQV CCCCCCCCCCCCHHH	23.74	28011693
548	Phosphorylation	IAKHLVPSEPSLQSS HHHHCCCCCCCCCCC	55.44	23776212
551	Phosphorylation	HLVPSEPSLQSSPAR HCCCCCCCCCCCCCC	34.68	23776212
554	Phosphorylation	PSEPSLQSSPAREEG CCCCCCCCCCCCCCC	43.51	23776212
555	Phosphorylation	SEPSLQSSPAREEGE CCCCCCCCCCCCCCC	15.04	23776212
566	Phosphorylation	EEGEVPESELDPDTR CCCCCCHHHCCHHHH	37.07	23776212
572	Phosphorylation	ESELDPDTRRRLLIL HHHCCHHHHHHEHHH	31.31	23776212
856	Phosphorylation	GSMRHTGSITALREL CCCCCCCHHHHHHHH	20.23	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CPL1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CPL1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPL1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DMS3_ARATH	DMS3	physical	18541146
XB31_ARATH	XBAT31	physical	18541146
MYB3_ARATH	MYB3	physical	18541146
NAC19_ARATH	NAC019	physical	18541146
NRPB1_ARATH	NRPB1	physical	15388846
SRRT_ARATH	SE	physical	23141542
DRB1_ARATH	HYL1	physical	23141542

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.