CP27A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CP27A_HUMAN
• UniProt AC: Q02318
• Protein Name: Sterol 26-hydroxylase, mitochondrial
• Gene Name: CYP27A1
• Organism: Homo sapiens (Human).
• Sequence Length: 531
• Subcellular Localization: Mitochondrion membrane.
• Protein Description: Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity..
• Protein Sequence: MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALPSDKATGAPGAGPGVRRRQRSLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQRQC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
280	Phosphorylation	DGWNAIFSFGKKLID HHHHHHHHHHHHHHH	27.29	-
283	Acetylation	NAIFSFGKKLIDEKL HHHHHHHHHHHHHHH	42.25	-
321	Phosphorylation	LLASGQLSPREAMGS HHHCCCCCHHHHHCC	17.64	20058876
387	Trimethylation	FAHMPLLKAVLKETL CCCHHHHHHHHHHHH	44.10	-
387	Methylation	FAHMPLLKAVLKETL CCCHHHHHHHHHHHH	44.10	-
391	Malonylation	PLLKAVLKETLRLYP HHHHHHHHHHHHHCC	41.89	26320211
439	Phosphorylation	SRDPTAFSEPESFQP ECCCCCCCCCCCCCC	50.18	-
453	Phosphorylation	PHRWLRNSQPATPRI CCHHHHCCCCCCCCC	30.98	28176443
509	Acetylation	APETGELKSVARIVL CCCCCCCCEEEEEEE	38.28	-
520	Acetylation	RIVLVPNKKVGLQFL EEEECCCCHHHHHHH	42.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CP27A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CP27A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CP27A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRDX4_HUMAN	PRDX4	physical	21988832
FAS_HUMAN	FASN	physical	26344197
QCR2_HUMAN	UQCRC2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• H00151: Cerebrotendinous xanthomatosis; Van Bogaert-Scherer-Epstein Disease
• OMIM Disease
• 213700: Cerebrotendinous xanthomatosis (CTX)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB06777: Chenodeoxycholic acid
• DB00169: Cholecalciferol
• DB00153: Ergocalciferol
• DB00082: Pegvisomant