CNBP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNBP_MOUSE
• UniProt AC: P53996
• Protein Name: Cellular nucleic acid-binding protein
• Gene Name: Cnbp
• Organism: Mus musculus (Mouse).
• Sequence Length: 178
• Subcellular Localization: Cytoplasm. Endoplasmic reticulum.
• Protein Description: Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression..
• Protein Sequence: MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGGFTSDRGFQFVSSSLPDICYRCGESGHLAKDCDLQEDEACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSNECFKC ------CCCCCCCCC	41.70	30635358
2	Acetylation	------MSSNECFKC ------CCCCCCCCC	41.70	23806337
3	Phosphorylation	-----MSSNECFKCG -----CCCCCCCCCC	35.04	30635358
8	Acetylation	MSSNECFKCGRSGHW CCCCCCCCCCCCCCC	47.65	23806337
8	Ubiquitination	MSSNECFKCGRSGHW CCCCCCCCCCCCCCC	47.65	-
25	Dimethylation	ECPTGGGRGRGMRSR CCCCCCCCCCCCCCC	34.60	-
25	Methylation	ECPTGGGRGRGMRSR CCCCCCCCCCCCCCC	34.60	18958363
27	Dimethylation	PTGGGRGRGMRSRGR CCCCCCCCCCCCCCC	34.08	-
27	Methylation	PTGGGRGRGMRSRGR CCCCCCCCCCCCCCC	34.08	18958371
32	Methylation	RGRGMRSRGRGGFTS CCCCCCCCCCCCCCC	28.59	25057285
32 (in isoform 2)	Methylation	-	28.59	24129315
32 (in isoform 2)	Dimethylation	-	28.59	-
32	Dimethylation	RGRGMRSRGRGGFTS CCCCCCCCCCCCCCC	28.59	-
34	Methylation	RGMRSRGRGGFTSDR CCCCCCCCCCCCCHH	40.74	12018953
34	Dimethylation	RGMRSRGRGGFTSDR CCCCCCCCCCCCCHH	40.74	-
34 (in isoform 2)	Dimethylation	-	40.74	-
34 (in isoform 2)	Methylation	-	40.74	24129315
40 (in isoform 2)	Phosphorylation	-	52.22	29514104
41 (in isoform 2)	Phosphorylation	-	47.82	23984901
42 (in isoform 2)	Phosphorylation	-	26.21	26824392
47	Phosphorylation	DRGFQFVSSSLPDIC HHCCHHHHCCCCHHH	18.59	26239621
48	Phosphorylation	RGFQFVSSSLPDICY HCCHHHHCCCCHHHH	30.50	26239621
49	Phosphorylation	GFQFVSSSLPDICYR CCHHHHCCCCHHHHH	36.09	25521595
54	Glutathionylation	SSSLPDICYRCGESG HCCCCHHHHHCCCCC	1.98	24333276
54	S-palmitoylation	SSSLPDICYRCGESG HCCCCHHHHHCCCCC	1.98	28526873
55	Phosphorylation	SSLPDICYRCGESGH CCCCHHHHHCCCCCC	14.85	25777480
57	Glutathionylation	LPDICYRCGESGHLA CCHHHHHCCCCCCCC	2.61	24333276
72 (in isoform 2)	Methylation	-	35.51	24129315
78	Glutathionylation	EDEACYNCGRGGHIA CCHHHHCCCCCCCHH	1.26	24333276
79 (in isoform 3)	Methylation	-	27.85	24129315
80	Methylation	EACYNCGRGGHIAKD HHHHCCCCCCCHHCC	50.55	12018963
88	S-nitrosocysteine	GGHIAKDCKEPKRER CCCHHCCCCCCCHHH	5.46	-
88	Glutathionylation	GGHIAKDCKEPKRER CCCHHCCCCCCCHHH	5.46	24333276
88	S-nitrosylation	GGHIAKDCKEPKRER CCCHHCCCCCCCHHH	5.46	21278135
99	Glutathionylation	KREREQCCYNCGKPG CHHHHHHHHHCCCCC	2.46	24333276
100	Phosphorylation	REREQCCYNCGKPGH HHHHHHHHHCCCCCC	22.55	29514104
102	Glutathionylation	REQCCYNCGKPGHLA HHHHHHHCCCCCCHH	2.75	24333276
104	Malonylation	QCCYNCGKPGHLARD HHHHHCCCCCCHHCC	50.45	26320211
104	Ubiquitination	QCCYNCGKPGHLARD HHHHHCCCCCCHHCC	50.45	-
104	Acetylation	QCCYNCGKPGHLARD HHHHHCCCCCCHHCC	50.45	22826441
112	Glutathionylation	PGHLARDCDHADEQK CCCHHCCCCCCCCHH	3.26	24333276
119	Acetylation	CDHADEQKCYSCGEF CCCCCCHHCCCCCCC	32.85	22826441
120	Glutathionylation	DHADEQKCYSCGEFG CCCCCHHCCCCCCCC	2.78	24333276
121	Phosphorylation	HADEQKCYSCGEFGH CCCCHHCCCCCCCCC	17.65	29514104
122	Phosphorylation	ADEQKCYSCGEFGHI CCCHHCCCCCCCCCC	25.72	20139300
123	Glutathionylation	DEQKCYSCGEFGHIQ CCHHCCCCCCCCCCC	2.15	24333276
123	S-palmitoylation	DEQKCYSCGEFGHIQ CCHHCCCCCCCCCCC	2.15	28526873
133	Glutathionylation	FGHIQKDCTKVKCYR CCCCCCCCCEEEEEE	5.23	24333276
141	S-nitrosylation	TKVKCYRCGETGHVA CEEEEEECCCCCCEE	2.03	24926564
144	Phosphorylation	KCYRCGETGHVAINC EEEECCCCCCEEEEC	20.19	20139300
151	S-palmitoylation	TGHVAINCSKTSEVN CCCEEEECCCCCCEE	3.45	28526873
151	Glutathionylation	TGHVAINCSKTSEVN CCCEEEECCCCCCEE	3.45	24333276
152	Phosphorylation	GHVAINCSKTSEVNC CCEEEECCCCCCEEE	34.18	25777480
159	S-nitrosocysteine	SKTSEVNCYRCGESG CCCCCEEEEECCCCC	2.47	-
159	Glutathionylation	SKTSEVNCYRCGESG CCCCCEEEEECCCCC	2.47	24333276
159	S-palmitoylation	SKTSEVNCYRCGESG CCCCCEEEEECCCCC	2.47	28526873
159	S-nitrosylation	SKTSEVNCYRCGESG CCCCCEEEEECCCCC	2.47	21278135
160	Phosphorylation	KTSEVNCYRCGESGH CCCCEEEEECCCCCC	12.07	29514104
162	Glutathionylation	SEVNCYRCGESGHLA CCEEEEECCCCCCEE	2.61	24333276
165	Phosphorylation	NCYRCGESGHLAREC EEEECCCCCCEEEEE	19.45	-
173	Phosphorylation	GHLARECTIEATA-- CCEEEEEEEEECC--	19.66	21183079
177	Phosphorylation	RECTIEATA------ EEEEEEECC------	21.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
173	T	Phosphorylation	Kinase	AMPKA1	Q13131	PSP
173	T	Phosphorylation	Kinase	PRKAA1	Q5EG47	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNBP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNBP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNBP_HUMAN	CNBP	physical	20360068
ANM1_HUMAN	PRMT1	physical	20360068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.