CLIC5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLIC5_HUMAN
• UniProt AC: Q9NZA1
• Protein Name: Chloride intracellular channel protein 5
• Gene Name: CLIC5
• Organism: Homo sapiens (Human).
• Sequence Length: 410
• Subcellular Localization: Isoform 1: Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Membrane ; Single-pass membrane protein . Associates with the cortical actin cytoskeleton. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transme
• Protein Description: Required for normal hearing. [PubMed: 24781754 It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture]
• Protein Sequence: MNDEDYSTIYDTIQNERTYEVPDQPEENESPHYDDVHEYLRPENDLYATQLNTHEYDFVSVYTIKGEETSLASVQSEDRGYLLPDEIYSELQEAHPGEPQEDRGISMEGLYSSTQDQQLCAAELQENGSVMKEDLPSPSSFTIQHSKAFSTTKYSCYSDAEGLEEKEGAHMNPEIYLFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPKLAAKHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGLTKALKKLDDYLNTPLPEEIDANTCGEDKGSRRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVAKRLSRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MNDEDYSTIYDTI --CCHHHHHHHHHHH	12.98	24043423
7	Phosphorylation	-MNDEDYSTIYDTIQ -CCHHHHHHHHHHHC	22.20	24043423
8	Phosphorylation	MNDEDYSTIYDTIQN CCHHHHHHHHHHHCC	19.82	24043423
10	Phosphorylation	DEDYSTIYDTIQNER HHHHHHHHHHHCCCE	13.71	24043423
12	Phosphorylation	DYSTIYDTIQNERTY HHHHHHHHHCCCEEE	13.90	24043423
33	Phosphorylation	EENESPHYDDVHEYL CCCCCCCCCCHHHHH	19.75	10930415
76	Phosphorylation	TSLASVQSEDRGYLL CCCCEEECCCCCCCC	39.03	-
88	Phosphorylation	YLLPDEIYSELQEAH CCCCHHHHHHHHHHC	8.27	-
111	Phosphorylation	GISMEGLYSSTQDQQ CCCCCHHCCCHHHHH	16.07	-
146	Phosphorylation	SSFTIQHSKAFSTTK CCEEEECCCCCCCCE	14.87	24719451
150	Phosphorylation	IQHSKAFSTTKYSCY EECCCCCCCCEEEEE	39.77	24719451
151	Phosphorylation	QHSKAFSTTKYSCYS ECCCCCCCCEEEEEC	22.36	24719451
157	Phosphorylation	STTKYSCYSDAEGLE CCCEEEEECCCCCCH	12.02	-
204	Acetylation	LFMILWLKGVVFNVT HHHHHHHHCCEEEEE	37.77	7710573
216	Acetylation	NVTTVDLKRKPADLH EEEEECCCCCCCCCC	54.64	7710585
270	Phosphorylation	LAAKHRESNTAGIDI HHHHHHCCCCCCCCH	39.16	-
272	Phosphorylation	AKHRESNTAGIDIFS HHHHCCCCCCCCHHH	35.22	-
279	Phosphorylation	TAGIDIFSKFSAYIK CCCCCHHHHHHHHHH	32.88	24719451
282	Phosphorylation	IDIFSKFSAYIKNTK CCHHHHHHHHHHCHH	24.73	24719451
333	Ubiquitination	EDKGSRRKFLDGDEL CCCCCCCCCCCCCCE	49.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
33	Y	Phosphorylation	Kinase	FYN	P06241	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLIC5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLIC5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLIC2_HUMAN	CLIC2	physical	26186194
TPRN_HUMAN	TPRN	physical	26186194
TPRN_HUMAN	TPRN	physical	28514442
CLIC2_HUMAN	CLIC2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616042: Deafness, autosomal recessive, 103 (DFNB103)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.