CLCB_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLCB_ARATH
• UniProt AC: P92942
• Protein Name: Chloride channel protein CLC-b
• Gene Name: CLC-B
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 780
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Voltage-gated chloride channel..
• Protein Sequence: MVEEDLNQIGGNSNYNGEGGDPESNTLNQPLVKANRTLSSTPLALVGAKVSHIESLDYEINENDLFKHDWRKRSKAQVLQYVFLKWTLACLVGLFTGLIATLINLAVENIAGYKLLAVGHFLTQERYVTGLMVLVGANLGLTLVASVLCVCFAPTAAGPGIPEIKAYLNGVDTPNMFGATTMIVKIVGSIGAVAAGLDLGKEGPLVHIGSCIASLLGQGGTDNHRIKWRWLRYFNNDRDRRDLITCGSAAGVCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVVVVLREFIEICNSGKCGLFGKGGLIMFDVSHVTYTYHVTDIIPVMLIGVIGGILGSLYNHLLHKVLRLYNLINEKGKIHKVLLSLTVSLFTSVCLYGLPFLAKCKPCDPSIDEICPTNGRSGNFKQFHCPKGYYNDLATLLLTTNDDAVRNLFSSNTPNEFGMGSLWIFFVLYCILGLFTFGIATPSGLFLPIILMGAAYGRMLGAAMGSYTSIDQGLYAVLGAAALMAGSMRMTVSLCVIFLELTNNLLLLPITMIVLLIAKTVGDSFNPSIYDIILHLKGLPFLEANPEPWMRNLTVGELGDAKPPVVTLQGVEKVSNIVDVLKNTTHNAFPVLDEAEVPQVGLATGATELHGLILRAHLVKVLKKRWFLTEKRRTEEWEVREKFPWDELAEREDNFDDVAITSAEMEMYVDLHPLTNTTPYTVMENMSVAKALVLFRQVGLRHLLIVPKIQASGMCPVVGILTRQDLRAYNILQAFPLLEKSKGGKTH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	PLVKANRTLSSTPLA CCHHCCCCCCCCCCH	30.69	23776212
39	Phosphorylation	VKANRTLSSTPLALV HHCCCCCCCCCCHHH	31.39	19880383
40	Phosphorylation	KANRTLSSTPLALVG HCCCCCCCCCCHHHC	36.84	23776212
41	Phosphorylation	ANRTLSSTPLALVGA CCCCCCCCCCHHHCC	20.95	23776212
561	Phosphorylation	VGDSFNPSIYDIILH HCCCCCHHHHHHHHH	34.58	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLCB_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLCB_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLCB_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDPK1_ARATH	CPK1	physical	22737156
GDU4_ARATH	GDU4	physical	22737156
CAAT6_ARATH	CAT6	physical	22737156
GCL1_ARATH	GCL1	physical	22737156
HHP4_ARATH	HHP4	physical	24833385
UBC34_ARATH	UBC34	physical	24833385
CNIH1_ARATH	AT3G12180	physical	24833385
CP21D_ARATH	AT3G66654	physical	24833385
SPCS1_ARATH	AT2G22425	physical	24833385
PPA3_ARATH	PAP3	physical	24833385
CRK40_ARATH	CRK40	physical	24833385
VAP21_ARATH	AT5G47180	physical	24833385
TBL18_ARATH	TBL18	physical	24833385
GRXC1_ARATH	AT5G63030	physical	24833385

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteomic analysis of nuclei-enriched fractions fromArabidopsis thaliana.";
Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A.,Andreasson E., Rathjen J.P., Peck S.C.;
J. Proteomics 72:439-451(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, AND MASSSPECTROMETRY.
PubMed: 19245862