CID_DROME - dbPTM
CID_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CID_DROME
UniProt AC Q9V6Q2
Protein Name Histone H3-like centromeric protein cid
Gene Name cid
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 225
Subcellular Localization Nucleus. Chromosome, centromere, kinetochore. Localizes exclusively in the kinetochore domain of centromeres. Co-expressed with yemalpha.
Protein Description Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division..
Protein Sequence MPRHSRAKRAPRPSANNSKSPNDDDTAFRSPEPEDGTDYGLEFTTSQLTLQDNNRRSSTLRRDAGRRQPAARDSSTSGEEEDQENRYPTTRSPQTRRMTVQQESKTRAAGPVAAQNQTRRRKAANPMSRAKRMDREIRRLQHHPGTLIPKLPFSRLVREFIVKYSDDEPLRVTEGALLAMQESCEMYLTQRLADSYMLTKHRNRVTLEVRDMALMAYICDRGRQF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationAKRAPRPSANNSKSP
CCCCCCCCCCCCCCC
44.9322817900
30PhosphorylationDDDTAFRSPEPEDGT
CCCCCCCCCCCCCCC
27.4522668510
74PhosphorylationRQPAARDSSTSGEEE
CCCCCCCCCCCCCHH
29.9322817900
75PhosphorylationQPAARDSSTSGEEED
CCCCCCCCCCCCHHH
30.7722817900
76PhosphorylationPAARDSSTSGEEEDQ
CCCCCCCCCCCHHHH
44.7122817900
77PhosphorylationAARDSSTSGEEEDQE
CCCCCCCCCCHHHHC
46.2722817900
99PhosphorylationSPQTRRMTVQQESKT
CHHHCEEEECHHHHH
17.2221082442
118PhosphorylationPVAAQNQTRRRKAAN
CHHHHHHHHHHHHCC
33.4225749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CID_DROME !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CID_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CID_DROME !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAF1_DROMECaf1physical
16601098
CID_DROMEcidphysical
19047461
SSRP1_DROMESsrpphysical
26586808
SPT16_DROMEdre4physical
26586808
CAF1_DROMECaf1physical
16775420
CAF1_DROMECaf1physical
26586808
NLP_DROMENlpphysical
23562326
MODU_DROMEmodphysical
26586808
MODU_DROMEmodphysical
23562326

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CID_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74; SER-75; THR-76 ANDSER-77, AND MASS SPECTROMETRY.

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