CI043_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CI043_HUMAN
• UniProt AC: Q8TAL5
• Protein Name: Uncharacterized protein C9orf43
• Gene Name: C9orf43
• Organism: Homo sapiens (Human).
• Sequence Length: 461
• Protein Sequence: MDLPDESQWDETTCGLAVCQHPQCWATIRRIERGHPRILGSSCKTPLDAEDKLPVLTVVDILDSGFAAHHLPECTFTKAHSLLSQSSKFYSKFHGRPPKGLPDKSLINCTNRLPKFPVLNLNETQLPCPEDVRNMVVLWIPEETEIHVSQHGKKKRKNSAVKSKSFLGLSGNQSAGTRVGTPGMIVPPPTPVQLSEQFSSDFLPLWAQSEALPQDLLKELLPGGKQTMLCPEMKIKLAMMKKNLPLEKNRPDSVISSKMFLSIHRLTLERPALRYPERLKKLHNLKTEGYRKQQQRQQQQQQQQKKVKTPIKKQEAKKKAKSDPGIQSTSHKHPVTTVHDRLYGYRTLPGQNSDMKQQQQMEKGTTSKQDSTERPKMNYYDHADFHHSVKSPELYETEPTNKDISAPVDAVPEAQAARQKKISFNFSEIMASTGWNSELKLLRILQDTDDEDEEDQSSGAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
159	Phosphorylation	GKKKRKNSAVKSKSF CCCCCCCCCCCCCCC	37.16	17924679
163	Phosphorylation	RKNSAVKSKSFLGLS CCCCCCCCCCCCCCC	27.25	17924679
165	Phosphorylation	NSAVKSKSFLGLSGN CCCCCCCCCCCCCCC	32.56	23612710
253	Phosphorylation	LEKNRPDSVISSKMF CCCCCCCHHHHHHHH	24.84	23898821
256	Phosphorylation	NRPDSVISSKMFLSI CCCCHHHHHHHHHHH	23.04	23898821
257	Phosphorylation	RPDSVISSKMFLSIH CCCHHHHHHHHHHHH	19.60	23898821
262	Phosphorylation	ISSKMFLSIHRLTLE HHHHHHHHHHHHHCC	12.70	23898821
280	Ubiquitination	LRYPERLKKLHNLKT HHCHHHHHHHHCCCC	60.55	-
281	Ubiquitination	RYPERLKKLHNLKTE HCHHHHHHHHCCCCH	60.62	-
329	Phosphorylation	SDPGIQSTSHKHPVT CCCCCCCCCCCCCCC	20.62	22210691
330	Phosphorylation	DPGIQSTSHKHPVTT CCCCCCCCCCCCCCE	35.47	22210691
345	Phosphorylation	VHDRLYGYRTLPGQN EEHHHHCCCCCCCCC	6.20	30576142
353	Phosphorylation	RTLPGQNSDMKQQQQ CCCCCCCCCHHHHHH	31.06	30576142
368	Acetylation	MEKGTTSKQDSTERP HHHCCCCCCCCCCCC	56.91	12655649

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CI043_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CI043_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CI043_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
RBG10_HUMAN	RABGAP1L	physical	25814554
RBG1L_HUMAN	RABGAP1L	physical	25814554
ACTA_HUMAN	ACTA2	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-159 AND SER-163, ANDMASS SPECTROMETRY.
PubMed: 17924679