| UniProt ID | CED3_CAEEL | |
|---|---|---|
| UniProt AC | P42573 | |
| Protein Name | Cell death protein 3 | |
| Gene Name | ced-3 {ECO:0000312|WormBase:C48D1.2a} | |
| Organism | Caenorhabditis elegans. | |
| Sequence Length | 503 | |
| Subcellular Localization | Nucleus membrane . Perikaryon . Cell junction, synapse . Mitochondrion . Cytoplasm . Cytoplasm, perinuclear region . Colocalizes with nucleoporin npp-14 to the perinuclear region in germ cells (PubMed:27723735). Becomes diffused in the cytoplasm in a | |
| Protein Description | Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. [PubMed: 8654923] | |
| Protein Sequence | MMRQDRRSLLERNIMMFSSHLKVDEILEVLIAKQVLNSDNGDMINSCGTVREKRREIVKAVQRRGDVAFDAFYDALRSTGHEGLAEVLEPLARSVDSNAVEFECPMSPASHRRSRALSPAGYTSPTRVHRDSVSSVSSFTSYQDIYSRARSRSRSRALHSSDRHNYSSPPVNAFPSQPSSANSSFTGCSSLGYSSSRNRSFSKASGPTQYIFHEEDMNFVDAPTISRVFDEKTMYRNFSSPRGMCLIINNEHFEQMPTRNGTKADKDNLTNLFRCMGYTVICKDNLTGRGMLLTIRDFAKHESHGDSAILVILSHGEENVIIGVDDIPISTHEIYDLLNAANAPRLANKPKIVFVQACRGERRDNGFPVLDSVDGVPAFLRRGWDNRDGPLFNFLGCVRPQVQQVWRKKPSQADILIAYATTAQYVSWRNSARGSWFIQAVCEVFSTHAKDMDVVELLTEVNKKVACGFQTSQGSNILKQMPEMTSRLLKKFYFWPEARNSAV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 107 | Phosphorylation | VEFECPMSPASHRRS EEEECCCCHHHHHCC | 11.49 | 30078680 | |
| 110 | Phosphorylation | ECPMSPASHRRSRAL ECCCCHHHHHCCCCC | 22.40 | 30078680 | |
| 118 | Phosphorylation | HRRSRALSPAGYTSP HHCCCCCCCCCCCCC | 16.24 | 30078680 | |
| 122 | Phosphorylation | RALSPAGYTSPTRVH CCCCCCCCCCCCCCC | 13.22 | 30078680 | |
| 123 | Phosphorylation | ALSPAGYTSPTRVHR CCCCCCCCCCCCCCC | 27.58 | 30078680 | |
| 124 | Phosphorylation | LSPAGYTSPTRVHRD CCCCCCCCCCCCCCC | 18.78 | 30078680 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CED3_CAEEL !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CED3_CAEEL !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CED3_CAEEL !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NOL3_HUMAN | NOL3 | genetic | 9560245 | |
| NOL3_HUMAN | NOL3 | physical | 9560245 | |
| CRADD_HUMAN | CRADD | physical | 8985253 | |
| C8AP2_HUMAN | CASP8AP2 | physical | 9027312 | |
| CED4_CAEEL | ced-4 | physical | 9027312 | |
| CASP1_HUMAN | CASP1 | physical | 9027312 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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