CDKL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDKL1_HUMAN
• UniProt AC: Q00532
• Protein Name: Cyclin-dependent kinase-like 1 {ECO:0000305}
• Gene Name: CDKL1 {ECO:0000312|HGNC:HGNC:1781}
• Organism: Homo sapiens (Human).
• Sequence Length: 358
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Sequence: MMEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLAGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEHNKPTRKTLRKSRKHHCFTETSKLQYLPQLTGSSILPALDNKKYYCDTKKLNYRFPNI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	VFKCRNRDTGQIVAI EEEEECCCCCCEEEE	27.96	23186163
27	Phosphorylation	FKCRNRDTGQIVAIK EEEECCCCCCEEEEE	21.36	-
35	Ubiquitination	GQIVAIKKFLESEDD CCEEEEEHHHHCCCC	8.54	-
161	Phosphorylation	GPSDYYTDYVATRWY CCCHHHHHHHHCCCC	5.56	-
301 (in isoform 2)	Phosphorylation	-	53.76	29116813
302 (in isoform 2)	Phosphorylation	-	50.07	29116813
318	Phosphorylation	KSRKHHCFTETSKLQ HHHHHHCCCCCCCCC	43.69	27794612
320	Phosphorylation	RKHHCFTETSKLQYL HHHHCCCCCCCCCCC	28.27	27794612
321	Phosphorylation	KHHCFTETSKLQYLP HHHCCCCCCCCCCCC	25.74	27794612
376 (in isoform 2)	Phosphorylation	-		18491316
552 (in isoform 2)	Phosphorylation	-		30243723

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDKL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDKL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDKL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIR1_HUMAN	SIRT1	physical	23602568
EDIL3_HUMAN	EDIL3	physical	23602568
PSB5_HUMAN	PSMB5	physical	23602568
FKBP5_HUMAN	FKBP5	physical	26186194
CDC37_HUMAN	CDC37	physical	26186194
SIR1_HUMAN	SIRT1	physical	26186194
SPT5H_HUMAN	SUPT5H	physical	26186194
TRIP6_HUMAN	TRIP6	physical	26186194
FKBP5_HUMAN	FKBP5	physical	28514442
SIR1_HUMAN	SIRT1	physical	28514442
CDKL4_HUMAN	CDKL4	physical	28514442
TRIP6_HUMAN	TRIP6	physical	28514442
ANR28_HUMAN	ANKRD28	physical	28514442
SPT5H_HUMAN	SUPT5H	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.