CAX1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAX1_ARATH
• UniProt AC: Q39253
• Protein Name: Vacuolar cation/proton exchanger 1
• Gene Name: CAX1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 463
• Subcellular Localization: Vacuole membrane ; Multi-pass membrane protein . Tonoplast.
• Protein Description: Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+) and other metal ions into vacuoles using the proton gradient formed by H(+)-ATPase and H(+)-pyrophosphatase. Involved in ion homeostasis in association with CAX3. May play a role in cold-acclimation response..
• Protein Sequence: MAGIVTEPWSVAENGNPSITAKGSSRELRLGRTAHNMSSSSLRKKSDLRVIQKVPYKGLKDFLSNLQEVILGTKLAILFPAIPAAIICTYCGVSQPWIFGLSLLGLTPLAERVSFLTEQLAFYTGPTLGGLLNATCGNATELIIAILALTNNKVAVVKYSLLGSILSNLLLVLGTSLFCGGIANIRREQRFDRKQADVNFFLLLLGFLCHLLPLLVGYLKNGEASAAVLSDMQLSISRGFSIVMLISYIAYLVFQLWTHRQLFDAQEQEDEYDDDVEQETAVISFWSGFAWLVGMTLVIALLSEYVVATIEEASDKWNLSVSFISIILLPIVGNAAEHAGAVIFAFKNKLDISLGVALGSATQIGLFVVPLTIIVAWILGINMDLNFGPLETGCLAVSIIITAFTLQDGSSHYMKGLVLLLCYFIIAICFFVDKLPQKQNAIHLGHQAMNNVVTATGGGVFSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGIVTEPW ------CCCCCCCCC	19.20	22223895
18	Phosphorylation	VAENGNPSITAKGSS HCCCCCCCCCCCCCC	36.25	30407730
20	Phosphorylation	ENGNPSITAKGSSRE CCCCCCCCCCCCCCH	27.01	30407730
24	Phosphorylation	PSITAKGSSRELRLG CCCCCCCCCCHHHCC	26.05	30407730
25	Phosphorylation	SITAKGSSRELRLGR CCCCCCCCCHHHCCC	38.14	30407730
38	Phosphorylation	GRTAHNMSSSSLRKK CCHHHCCCHHHHCCH	32.17	30407730
39	Phosphorylation	RTAHNMSSSSLRKKS CHHHCCCHHHHCCHH	17.12	29654922
40	Phosphorylation	TAHNMSSSSLRKKSD HHHCCCHHHHCCHHC	26.53	30407730
41	Phosphorylation	AHNMSSSSLRKKSDL HHCCCHHHHCCHHCC	33.85	30407730
318	N-linked_Glycosylation	EEASDKWNLSVSFIS HHHHHHCCCCHHHHH	28.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAX1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAX1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAX1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAX3_ARATH	CAX3	physical	19098009
CAX1_ARATH	CAX1	physical	12006570
GRS14_ARATH	CXIP1	physical	12480930
CAX3_ARATH	CAX3	physical	19819871
CAX1_ARATH	CAX1	physical	19819871
CNG13_ARATH	CNGC13	physical	22737156
CAAT6_ARATH	CAT6	physical	22737156

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.