CAMK3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAMK3_ARATH
• UniProt AC: Q9ZUZ2
• Protein Name: CDPK-related kinase 3
• Gene Name: CRK3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 595
• Subcellular Localization: Cytoplasm . Membrane; Lipid-anchor; Cytoplasmic side.
• Protein Description: May play a role in signal transduction pathways that involve calcium as a second messenger (By similarity). Serine/threonine kinase that phosphorylates histone H3 an GLN1-1..
• Protein Sequence: MGQCYGKVNQSKQNGEEEANTTTYVVSGDGNQIQPLTPVNYGRAKNTPARSSNPSPWPSPFPHGSASPLPSGVSPSPARTSTPRRFFRRPFPPPSPAKHIKASLIKRLGVKPKEGPIPEERGTEPEQSLDKSFGYGKNFGAKYELGKEVGRGHFGHTCSGRGKKGDIKDHPIAVKIISKAKMTTAIAIEDVRREVKLLKSLSGHKYLIKYYDACEDANNVYIVMELCDGGELLDRILARGGKYPEDDAKAIVVQILTVVSFCHLQGVVHRDLKPENFLFTSSREDSDLKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSLEADIWSIGVITYILLCGSRPFWARTESGIFRTVLRTEPNYDDVPWPSCSSEGKDFVKRLLNKDYRKRMSAVQALTHPWLRDDSRVIPLDILIYKLVKAYLHATPLRRAALKALAKALTENELVYLRAQFMLLGPNKDGSVSLENFKTALMQNATDAMRESRVPEILHTMESLAYRKMYFEEFCAAAISIHQLEAVDAWEEIATAGFQHFETEGNRVITIEELARELNVGASAYGHLRDWVRSSDGKLSYLGFTKFLHGVTLRAAHARPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGQCYGKVN ------CCCCCCCCC		-
95	Phosphorylation	RRPFPPPSPAKHIKA CCCCCCCCHHHHHHH		23111157
311	Phosphorylation	RLNDIVGSAYYVAPE HHHHHCCCHHHCCHH		-
351	Phosphorylation	SRPFWARTESGIFRT CCCHHEECCCCCCEE		15308754
353	Phosphorylation	PFWARTESGIFRTVL CHHEECCCCCCEEEC		15308754
497	Phosphorylation	EILHTMESLAYRKMY HHHHHHHHHHHHHHH		23572148
500	Phosphorylation	HTMESLAYRKMYFEE HHHHHHHHHHHHHHH		23572148
574	Phosphorylation	RSSDGKLSYLGFTKF HCCCCCEEEEEHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
353	S	Phosphorylation	Kinase	CPK1	Q06850	Uniprot
353	S	Phosphorylation	Kinase	CPK34	Q3E9C0	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAMK3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAMK3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLN11_ARATH	GSR 1	physical	16472779
CAMK3_ARATH	CRK3	physical	25969537
TBB7_ARATH	TUB7	physical	25969537
TBB9_ARATH	TUB9	physical	25969537

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.