dbPTM

CADH6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CADH6_HUMAN
UniProt AC	P55285
Protein Name	Cadherin-6
Gene Name	CDH6
Organism	Homo sapiens (Human).
Sequence Length	790
Subcellular Localization	Cell membrane Single-pass type I membrane protein.
Protein Description	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types..
Protein Sequence	MRTYRYFLLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYGGVDSDKDS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MRTYRYFLLLFWV --CCCEEEHHHHHHC	6.54	24719451
28	O-linked_Glycosylation	STPLSKRTSGFPAKK CCCHHHCCCCCCHHH	36.62	30620550
29	O-linked_Glycosylation	TPLSKRTSGFPAKKR CCHHHCCCCCCHHHH	42.33	30620550
35	Methylation	TSGFPAKKRALELSG CCCCCHHHHHHHHCC	45.04	-
44	Phosphorylation	ALELSGNSKNELNRS HHHHCCCCHHHHCHH	40.14	23612710
49	N-linked_Glycosylation	GNSKNELNRSKRSWM CCCHHHHCHHHHHHH	39.75	UniProtKB CARBOHYD
90	Phosphorylation	RGDGSLKYILSGDGA CCCCCEEEEEECCCC	16.64	22210691
143	Phosphorylation	GRPVEPESEFIIKIH CCCCCCCCEEEEEEE	48.82	27251275
255	N-linked_Glycosylation	LSGTTTVNITLTDVN CCCCEEEEEEEECCC	21.31	UniProtKB CARBOHYD
285	Phosphorylation	PESSPPGTPIGRIKA CCCCCCCCCCEEEEC	19.94	18785766
343	Phosphorylation	DFEKKKVYTLKVEAS CCCCCEEEEEEEEEC	18.42	22817900
350	Phosphorylation	YTLKVEASNPYVEPR EEEEEEECCCCCCCC	25.49	30631047
360	Phosphorylation	YVEPRFLYLGPFKDS CCCCCEEEEECCCCC	13.60	21406692
367	Phosphorylation	YLGPFKDSATVRIVV EEECCCCCCEEEEEE	26.82	21406692
369	Phosphorylation	GPFKDSATVRIVVED ECCCCCCEEEEEEEC	17.80	21406692
399	N-linked_Glycosylation	IREDAQINTTIGSVT HHCCCCCCCEEEEEE	21.06	16335952
425	Phosphorylation	KYSVDRHTDMDRIFN EEEEECCCCHHHEEE	33.63	-
437	N-linked_Glycosylation	IFNIDSGNGSIFTSK EEEEECCCCCEEEHH	45.02	UniProtKB CARBOHYD
455	N-linked_Glycosylation	RETLLWHNITVIATE CCHHHEECEEEEEEE	21.75	UniProtKB CARBOHYD
536	N-linked_Glycosylation	PEAASGSNFTIQDNK CCCCCCCCCEEECCC	41.42	UniProtKB CARBOHYD
648	Phosphorylation	KKEPLIISKEDIRDN HCCCCEEEHHHHHHC	24.01	28060719
649	Ubiquitination	KEPLIISKEDIRDNI CCCCEEEHHHHHHCC	49.34	32142685
669	Phosphorylation	EGGGEEDTQAFDIGT CCCCCCCCCEEECCC	25.69	28857561
687	Ubiquitination	PEAIEDNKLRRDIVP HHHHCCCCCCCCCCC	56.55	32142685
703	Phosphorylation	ALFLPRRTPTARDNT HHCCCCCCCCCCCCC	26.69	22199227
705	Phosphorylation	FLPRRTPTARDNTDV CCCCCCCCCCCCCCH	33.44	22199227
781	Phosphorylation	FKKLADMYGGVDSDK HHHHHHHHCCCCCCC	15.98	28060719
786	Phosphorylation	DMYGGVDSDKDS--- HHHCCCCCCCCC---	44.12	28355574
790	Phosphorylation	GVDSDKDS------- CCCCCCCC-------	48.11	29970186

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CADH6_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CADH6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CADH6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CADH6_HUMAN	CDH6	physical	10207020
CAD18_HUMAN	CDH18	physical	10207020

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CADH6_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-399, AND MASSSPECTROMETRY.	16335952 [Abstract]