CAD18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAD18_HUMAN
• UniProt AC: Q13634
• Protein Name: Cadherin-18
• Gene Name: CDH18
• Organism: Homo sapiens (Human).
• Sequence Length: 790
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types..
• Protein Sequence: MKITSTSCICPVLVCLCFVQRCYGTAHHSSIKVMRNQTKHIEGETEVHHRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSKKEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSDQDYHYLGDWGPEFKKLAELYGEIESERTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	N-linked_Glycosylation	SSIKVMRNQTKHIEG HHHHEEECCCCCEEC	35.46	UniProtKB CARBOHYD
87	Phosphorylation	NSDKGDGSVKYILTG CCCCCCCEEEEEEEC	21.85	22617229
199	Phosphorylation	GNSARVVYSILQGQP CCCHHHHHHHHCCCC	6.27	-
214	Phosphorylation	YFSVDPKTGVIRTAL CEEECCCCCHHHHHH	41.91	22210691
255	N-linked_Glycosylation	LSGSTTVNITLTDVN CCCCEEEEEEEEECC	21.31	UniProtKB CARBOHYD
305	Phosphorylation	GSNADMTYSIINGDG CCCCCCEEEEECCCC	7.40	30576142
306	Phosphorylation	SNADMTYSIINGDGM CCCCCEEEEECCCCC	14.07	30576142
317	Phosphorylation	GDGMGIFSISTDKET CCCCEEEEEECCCCC	17.44	30576142
330	Phosphorylation	ETREGILSLKKPLNY CCHHHHHHCCCCCCC	35.90	24719451
365	Ubiquitination	FSHLGPFKDATMLKI EHHCCCCCCCEEEEE	49.97	2190698
388	Phosphorylation	PLFSMPSYLMEVYEN CCCCCCHHHHHHHHH	12.28	19658100
455	N-linked_Glycosylation	REETPWYNITVTASE CCCCCCEEEEEEHHH	21.42	UniProtKB CARBOHYD
536	N-linked_Glycosylation	ERLPVNPNFTLKDNE CCCCCCCCCEECCCC	37.01	UniProtKB CARBOHYD
548	Phosphorylation	DNEDNTASILTRRRR CCCCCCHHHHHHHHH	18.98	24719451
639	Phosphorylation	LFITLRRSKKEPLII HHHHHHHCCCCCEEE	41.46	-
647	Phosphorylation	KKEPLIISEEDVREN CCCCEEECHHHHHHC	28.12	-
674	Phosphorylation	DTEAFDITALRNPSA CCCEEEEEECCCCCH	22.83	24719451
786	Phosphorylation	ELYGEIESERTT--- HHHHHHHCCCCC---	37.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAD18_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAD18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAD18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAD18_HUMAN	CDH18	physical	10207020
MYOG_HUMAN	MYOG	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.