CABP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CABP1_HUMAN
• UniProt AC: Q9NZU7
• Protein Name: Calcium-binding protein 1
• Gene Name: CABP1
• Organism: Homo sapiens (Human).
• Sequence Length: 370
• Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Cell membrane ; Lipid-anchor; Cytoplasmic side. Golgi apparatus . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . L-CaBP1 is associated most likely with the cytoskel
• Protein Description: Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs)(PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling. [PubMed: 15980432 Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels]
• Protein Sequence: MGGGDGAAFKRPGDGARLQRVLGLGSRREPRSLPAGGPAPRRTAPPPPGHASAGPAAMSSHIAKSESKTSLLKAAAAAASGGSRAPRHGPARDPGLPSRRLPGSCPATPQSSGDPSSRRPLCRPAPREEGARGSQRVLPQAHCRPREALPAAASRPSPSSPLPPARGRDGEERGLSPALGLRGSLRARGRGDSVPAAASEADPFLHRLRPMLSSAFGQDRSLRPEEIEELREAFREFDKDKDGYINCRDLGNCMRTMGYMPTEMELIELSQQINMNLGGHVDFDDFVELMGPKLLAETADMIGVKELRDAFREFDTNGDGEISTSELREAMRKLLGHQVGHRDIEEIIRDVDLNGDGRVDFEEFVRMMSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGGGDGAAF ------CCCCCCCCC	49.11	-
2 (in isoform 1)	Myristoylation	-	49.11	10625670
2 (in isoform 2)	Myristoylation	-	49.11	10625670
4 (in isoform 1)	S-palmitoylation	-	25.17	10625670
4 (in isoform 2)	S-palmitoylation	-	25.17	10625670
31	Methylation	LGSRREPRSLPAGGP CCCCCCCCCCCCCCC	46.18	-
70	Phosphorylation	AKSESKTSLLKAAAA HCCCCHHHHHHHHHH	35.13	24719451
87	Dimethylation	SGGSRAPRHGPARDP HCCCCCCCCCCCCCC	46.54	-
92	Dimethylation	APRHGPARDPGLPSR CCCCCCCCCCCCCCC	54.51	-
98	Phosphorylation	ARDPGLPSRRLPGSC CCCCCCCCCCCCCCC	34.77	-
176	Phosphorylation	DGEERGLSPALGLRG CCCCCCCCHHHCHHH	15.79	28857561
180	Phosphorylation	RGLSPALGLRGSLRA CCCCHHHCHHHHHHH	18.55	14685260
190	Methylation	GSLRARGRGDSVPAA HHHHHCCCCCCCCHH	39.94	-
323	Phosphorylation	TNGDGEISTSELREA CCCCCCCCHHHHHHH	22.90	10625670

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CABP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CABP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CABP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAC1C_HUMAN	CACNA1C	physical	15140941
CAC1A_HUMAN	CACNA1A	physical	14570872
CAC1A_HUMAN	CACNA1A	physical	11865310
GRK5_HUMAN	GRK5	physical	10625670
ITPR1_HUMAN	ITPR1	physical	12032348
UBP4_HUMAN	USP4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Regulation of InsP3 receptor activity by neuronal Ca2+-bindingproteins.";
Kasri N.N., Holmes A.M., Bultynck G., Parys J.B., Bootman M.D.,Rietdorf K., Missiaen L., McDonald F., De Smedt H., Conway S.J.,Holmes A.B., Berridge M.J., Roderick H.L.;
EMBO J. 23:312-321(2004).
Cited for: PHOSPHORYLATION AT SER-323, MUTAGENESIS OF SER-323, SUBCELLULARLOCATION, AND INTERACTION WITH ITPR1.
PubMed: 14685260