dbPTM

CA105_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CA105_HUMAN
UniProt AC	O95561
Protein Name	Uncharacterized protein C1orf105
Gene Name	C1orf105
Organism	Homo sapiens (Human).
Sequence Length	183
Subcellular Localization
Protein Description
Protein Sequence	MEKRELKASVPKFDKIPWLSEASLVNKPLVLSLPRRYPHTSATFLTSSKKNMNLPILFQVPDVLSKARRNQCDSMLLRNQQLCSTCQEMKMVQPRTMKIPDDPKASFENCMSYRMSLHQPKFQTTPEPFHDDIPTESIHYRLPILGPRTAVFHGLLTEAYKTLKERQRSSLPRKEPIGKTTRQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	VNKPLVLSLPRRYPH CCCCEEEECCCCCCC	28.93	24719451
74	Phosphorylation	ARRNQCDSMLLRNQQ HHHCHHHHHHHHHHH	20.96	-
98	Acetylation	MVQPRTMKIPDDPKA CCCCCCCCCCCCCCC	50.93	19827457
162	Phosphorylation	LLTEAYKTLKERQRS HHHHHHHHHHHHHHH	30.31	26074081
169	Phosphorylation	TLKERQRSSLPRKEP HHHHHHHHCCCCCCC	28.08	23927012
170	Phosphorylation	LKERQRSSLPRKEPI HHHHHHHCCCCCCCC	44.58	29496963

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CA105_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CA105_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CA105_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
LIMD1_HUMAN	LIMD1	physical	26186194
LIMD1_HUMAN	LIMD1	physical	28514442
TRI68_HUMAN	TRIM68	physical	28514442

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CA105_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169 AND SER-170, ANDMASS SPECTROMETRY.	17081983 [Abstract]