BAG1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BAG1_MOUSE
• UniProt AC: Q60739
• Protein Name: BAG family molecular chaperone regulator 1
• Gene Name: Bag1
• Organism: Mus musculus (Mouse).
• Sequence Length: 355
• Subcellular Localization: Isoform 1: Nucleus.; Isoform 2: Cytoplasm.
• Protein Description: Co-chaperone for HSP70 and HSC70 chaperone proteins. [PubMed: 9873016 Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli (By similarity]
• Protein Sequence: MAGRSAARRPRGDREPLGPRLRAPRPAREPRQSESRAERGLPPSQRSSVRSAASGHDRSTRGAPAGACKPRVKKKVRPRSSQSEKVGSSSRELTRSKKVTRSKNVTGTQVEEVTKIEEATQTEEVTVAEEVTQTDNMAKTEEMVQTEEMETPRLSVIVTHSNERYDLLVTPQQGNSEPVVQDLAQLVEEATGVPLPFQKLIFKGKSLKEMETPLSALGMQNGCRVMLIGEKSNPEEEVELKKLKDLEVSAEKIANHLQELNKELSGIQQGFLAKELQAEALCKLDRKVKATIEQFMKILEEIDTMVLPEQFKDSRLKRKNLVKKVQVFLAECDTVEQYICQETERLQSTNLALAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAGRSAARRPRG ---CCCCCCCCCCCC	25.93	24719451
96	Phosphorylation	SSRELTRSKKVTRSK CHHHHHHCCCCCCCC	31.43	-
100	Phosphorylation	LTRSKKVTRSKNVTG HHHCCCCCCCCCCCC	37.80	-
102	Phosphorylation	RSKKVTRSKNVTGTQ HCCCCCCCCCCCCCC	21.15	-
155	Phosphorylation	EMETPRLSVIVTHSN CCCCCCEEEEEEECC	15.86	-
223	Glutathionylation	ALGMQNGCRVMLIGE HHHCCCCCEEEEEEC	3.77	24333276
283	Ubiquitination	LQAEALCKLDRKVKA HHHHHHHHHCHHHHH	55.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BAG1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BAG1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BAG1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCL2_MOUSE	Bcl2	physical	7834747
HBEGF_HUMAN	HBEGF	physical	23277101
JUN_MOUSE	Jun	physical	20516211

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.