dbPTM

ATLA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATLA1_HUMAN
UniProt AC	Q8WXF7
Protein Name	Atlastin-1
Gene Name	ATL1
Organism	Homo sapiens (Human).
Sequence Length	558
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein . Golgi apparatus membrane Multi-pass membrane protein . Cell projection, axon . Localizes to endoplasmic reticulum tubular network (PubMed:27619977).
Protein Description	GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. [PubMed: 27619977 May also regulate Golgi biogenesis. May regulate axonal development.]
Protein Sequence	MAKNRRDRNSWGGFSEKTYEWSSEEEEPVKKAGPVQVLIVKDDHSFELDETALNRILLSEAVRDKEVVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIWSEIFLINKPDGKKVAVLLMDTQGTFDSQSTLRDSATVFALSTMISSIQVYNLSQNVQEDDLQHLQLFTEYGRLAMEETFLKPFQSLIFLVRDWSFPYEFSYGADGGAKFLEKRLKVSGNQHEELQNVRKHIHSCFTNISCFLLPHPGLKVATNPNFDGKLKEIDDEFIKNLKILIPWLLSPESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGVKKMGGEEFSRRYLQQLESEIDELYIQYIKHNDSKNIFHAARTPATLFVVIFITYVIAGVTGFIGLDIIASLCNMIMGLTLITLCTWAYIRYSGEYRELGAVIDQVAAALWDQGSTNEALYKLYSAAATHRHLYHQAFPTPKSESTEQSEKKKM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	KNRRDRNSWGGFSEK CCCCCCCCCCCCCCC	28.17	23401153
15	Phosphorylation	RNSWGGFSEKTYEWS CCCCCCCCCCCCCCC	41.27	23927012
18	Phosphorylation	WGGFSEKTYEWSSEE CCCCCCCCCCCCCCC	23.71	23090842
19	Phosphorylation	GGFSEKTYEWSSEEE CCCCCCCCCCCCCCC	26.86	23090842
22	Phosphorylation	SEKTYEWSSEEEEPV CCCCCCCCCCCCCCC	18.87	25159151
23	Phosphorylation	EKTYEWSSEEEEPVK CCCCCCCCCCCCCCC	50.53	25159151
45	Phosphorylation	LIVKDDHSFELDETA EEEECCCCCCCCHHH	27.66	-
59	Phosphorylation	ALNRILLSEAVRDKE HHHHHHHHHHHCCCC	21.77	23909892
71	Phosphorylation	DKEVVAVSVAGAFRK CCCEEEEEEEHHHHC	9.12	-
287	Ubiquitination	PNFDGKLKEIDDEFI CCCCCCCCCCCHHHH	56.99	-
334	Ubiquitination	EYFKAYIKIYQGEEL HHHHHHHHHHCCCCC	23.76	21890473
334	Ubiquitination	EYFKAYIKIYQGEEL HHHHHHHHHHCCCCC	23.76	21890473
346	Phosphorylation	EELPHPKSMLQATAE CCCCCCHHHHHHHHH	29.22	22210691
351	Phosphorylation	PKSMLQATAEANNLA CHHHHHHHHHHHCHH	16.45	22210691
362	Phosphorylation	NNLAAVATAKDTYNK HCHHHHHHHHHHCHH	27.86	30622161
395	Acetylation	QTKHLQLKEESVKLF CCCCHHHHHHHHHHH	46.61	-
400	Ubiquitination	QLKEESVKLFRGVKK HHHHHHHHHHHHHHH	51.71	-
414	Phosphorylation	KMGGEEFSRRYLQQL HHCHHHHHHHHHHHH	21.09	-
429	Phosphorylation	ESEIDELYIQYIKHN HHHHHHHHHHHHHHC	5.50	-
432	Phosphorylation	IDELYIQYIKHNDSK HHHHHHHHHHHCCCC	11.46	-
520 (in isoform 2)	Phosphorylation	-	43.85	26503514
544	Phosphorylation	LYHQAFPTPKSESTE HHHCCCCCCCCCCCC	36.57	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ATLA1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ATLA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATLA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SEY1_YEAST	SEY1	genetic	22508509
YOP1_YEAST	YOP1	genetic	22508509

Drug and Disease Associations

Kegg Disease
H00266	Hereditary spastic paraplegia (SPG)
OMIM Disease
182600	Spastic paraplegia 3, autosomal dominant (SPG3)
613708	Neuropathy, hereditary sensory, 1D (HSN1D)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATLA1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-23, AND MASSSPECTROMETRY.	18088087 [Abstract]