ATCAY_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATCAY_HUMAN
• UniProt AC: Q86WG3
• Protein Name: Caytaxin
• Gene Name: ATCAY
• Organism: Homo sapiens (Human).
• Sequence Length: 371
• Subcellular Localization: Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Cytoplasm . Mitochondrion envelope . Localizes presynaptically into neuron projections.
• Protein Description: Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites..
• Protein Sequence: MGTTEATLRMENVDVKEEWQDEDLPRPLPEETGVELLGSPVEDTSSPPNTLNFNGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLGNGNELEWEDDTPVATAKNMPGDSADLFGDGTTEDGSAANGRLWRTVIIGEQEHRIDLHMIRPYMKVVTHGGYYGEGLNAIIVFAACFLPDSSLPDYHYIMENLFLYVISSLELLVAEDYMIVYLNGATPRRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFISVKFINKIQYVHSLEDLEQLIPMEHVQIPDCVLQYEEERLKARRESARPQPEFVLPRSEEKPEVAPVENRSALVSEDQETSMS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
134	Phosphorylation	AKNMPGDSADLFGDG CCCCCCCCCCCCCCC	29.60	-
239	Phosphorylation	IVYLNGATPRRRMPG EEEECCCCCCCCCCC	20.80	-
252	Methylation	PGIGWLKKCYQMIDR CCCHHHHHHHHHHHH	35.68	-
284	Phosphorylation	IRTVLAISRPFISVK HHHHHHHCCCEEEEE	28.44	24719451
368	Phosphorylation	LVSEDQETSMS---- CCCCCHHCCCC----	24.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:16275660

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATCAY_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATCAY_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHIP_HUMAN	STUB1	physical	16275660
A4_HUMAN	APP	physical	21832049
PIN1_HUMAN	PIN1	physical	18628984
ATCAY_HUMAN	ATCAY	physical	18628984
GLSK_HUMAN	GLS	physical	18628984

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.