ASB16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASB16_HUMAN
• UniProt AC: Q96NS5
• Protein Name: Ankyrin repeat and SOCS box protein 16
• Gene Name: ASB16
• Organism: Homo sapiens (Human).
• Sequence Length: 453
• Protein Description: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
• Protein Sequence: MARETFPFTSSMLRSLRLQQEWLEWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPAVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPEMLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEGCIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	Sumoylation	WVLTPKTKQTAPLAI EEECCCCCCCCCCHH	52.34	-
319	Phosphorylation	VPNGAGHTPMDCALQ CCCCCCCCCHHHHHH	21.28	-
378	Phosphorylation	NAYPCVPSCETWVEA HHCCCCCCHHHHHHH	12.27	-
398	Phosphorylation	WKEHEAFYSSALCMV HHHCHHHHHHHHHHH	14.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASB16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASB16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASB16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL5_HUMAN	CUL5	physical	24337577
HIF1N_HUMAN	HIF1AN	physical	24337577
ELOC_HUMAN	TCEB1	physical	24337577
ELOB_HUMAN	TCEB2	physical	24337577
H33_HUMAN	H3F3A	physical	24337577
VIME_HUMAN	VIM	physical	24337577
H2B1N_HUMAN	HIST1H2BN	physical	24337577
H2AZ_HUMAN	H2AFZ	physical	24337577
PGAM1_HUMAN	PGAM1	physical	24337577
KCRB_HUMAN	CKB	physical	24337577
SVIL_HUMAN	SVIL	physical	24337577
FRIH_HUMAN	FTH1	physical	24337577
XPO2_HUMAN	CSE1L	physical	24337577
G3P_HUMAN	GAPDH	physical	24337577
RAN_HUMAN	RAN	physical	24337577
H12_HUMAN	HIST1H1C	physical	24337577
SAHH_HUMAN	AHCY	physical	24337577
HIF1N_HUMAN	HIF1AN	physical	28514442
SPDLY_HUMAN	SPDL1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.