| UniProt ID | ARH38_HUMAN | |
|---|---|---|
| UniProt AC | Q9NXL2 | |
| Protein Name | Rho guanine nucleotide exchange factor 38 | |
| Gene Name | ARHGEF38 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 777 | |
| Subcellular Localization | ||
| Protein Description | May act as a guanine-nucleotide releasing factor.. | |
| Protein Sequence | MEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSGDHSGTLRRSQSDRTEYNQKLQEKMTPQGECSVAETLTPEEEHHMKRMMAKREKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLDVDSLFSNIESVHQISAKLLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLSHCIQSLKKIYMQEGKPNLLDMGSLMIKPIQRVMKYPLLLCELRNSTPPSHPDYRALDDAFAAVKDINVNINELKRRKDLVLKYKKNDEDESLKDKLSKLNIHSISKKSKRVTNHLKILTRGESQVKDNTFNREEKLFRALEKTVRLCVKNISLCLQHIQDAMPLALQSVMDLQEISYNKDDEMDYSETLSNALNSCHDFASHLQRLILTPLSALLSLFPGPHKLIQKRYDKLLDCNSYLQRSTGEESDLAKKEYEALNAQLVEELQAFNQAARKILLNCLCSFITLLRDLMLVAQQAYSTLVPMPLLVSSISEIQNQVLEEIQNLNCVKENSATFIERKLSFEKKKPVQILPEMPHQTDIHRSKLLSTYSAEELYQAKRKCNATQEYDINLLEGDLVAVIEQKDPLGSTSRWLVDTGNVKGYVYSSFLKPYNPAKMQKVDAENRFCDDDFENISLFVSSRPASDSVTGTSESSIGDSSSSLSGTCGKFETNGTDVDSFQEVDEQIFYAVHAFQARSDHELSLQEYQRVHILRFCDLSGNKEWWLAEAQGQKGYVPANYLGKMTYA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 34 | Phosphorylation | YMLERRKTDTVVESS HHHHHCCCCCEEECC | 34.78 | 26657352 | |
| 34 (in isoform 2) | Phosphorylation | - | 34.78 | 20736484 | |
| 36 | Phosphorylation | LERRKTDTVVESSVS HHHCCCCCEEECCCC | 31.51 | 29496963 | |
| 36 (in isoform 2) | Phosphorylation | - | 31.51 | 20736484 | |
| 40 | Phosphorylation | KTDTVVESSVSGDHS CCCCEEECCCCCCCC | 25.16 | 27251275 | |
| 41 | Phosphorylation | TDTVVESSVSGDHSG CCCEEECCCCCCCCC | 13.54 | 27251275 | |
| 43 | Phosphorylation | TVVESSVSGDHSGTL CEEECCCCCCCCCCC | 40.21 | 23312004 | |
| 47 (in isoform 2) | Phosphorylation | - | 37.91 | - | |
| 47 | Phosphorylation | SSVSGDHSGTLRRSQ CCCCCCCCCCCCCCC | 37.91 | 30576142 | |
| 49 | Phosphorylation | VSGDHSGTLRRSQSD CCCCCCCCCCCCCCC | 21.80 | 23312004 | |
| 49 (in isoform 2) | Phosphorylation | - | 21.80 | - | |
| 53 (in isoform 2) | Phosphorylation | - | 27.83 | - | |
| 53 | Phosphorylation | HSGTLRRSQSDRTEY CCCCCCCCCCCHHHH | 27.83 | 30576142 | |
| 55 | Phosphorylation | GTLRRSQSDRTEYNQ CCCCCCCCCHHHHHH | 30.24 | 33259812 | |
| 55 (in isoform 2) | Phosphorylation | - | 30.24 | 20736484 | |
| 58 | Phosphorylation | RRSQSDRTEYNQKLQ CCCCCCHHHHHHHHH | 48.05 | 28509920 | |
| 60 | Phosphorylation | SQSDRTEYNQKLQEK CCCCHHHHHHHHHHH | 23.45 | 28509920 | |
| 69 | Phosphorylation | QKLQEKMTPQGECSV HHHHHHCCCCCCCCH | 24.43 | 24425749 | |
| 189 | Phosphorylation | DIYKIYCYHHDEAHS HHHEEEEEEHHHHHH | 5.80 | 25332170 | |
| 201 | Phosphorylation | AHSILESYEKEEELK HHHHHHHHHCHHHHH | 22.96 | 25332170 | |
| 219 (in isoform 2) | Acetylation | - | 64.64 | - | |
| 219 | Acetylation | SHCIQSLKKIYMQEG HHHHHHHHHHHHHCC | 64.64 | 20167786 | |
| 265 | Phosphorylation | TPPSHPDYRALDDAF CCCCCCCHHHHHHHH | - | ||
| 315 | Phosphorylation | LSKLNIHSISKKSKR HHHCCHHHHCCCCCH | 27251275 | ||
| 315 (in isoform 2) | Phosphorylation | - | 27251275 | ||
| 317 | Phosphorylation | KLNIHSISKKSKRVT HCCHHHHCCCCCHHH | 24719451 | ||
| 317 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 335 | Phosphorylation | KILTRGESQVKDNTF HHHHCCCHHHCCCCC | 28857561 | ||
| 335 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 355 | Phosphorylation | LFRALEKTVRLCVKN HHHHHHHHHHHHHHH | 29396449 | ||
| 421 | Phosphorylation | HLQRLILTPLSALLS HHHHHHHHHHHHHHH | 29978859 | ||
| 424 | Phosphorylation | RLILTPLSALLSLFP HHHHHHHHHHHHHCC | 29978859 | ||
| 441 | Phosphorylation | HKLIQKRYDKLLDCN HHHHHHHHHHHHCCC | - | ||
| 441 (in isoform 2) | Phosphorylation | - | - | ||
| 553 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 553 | Phosphorylation | TFIERKLSFEKKKPV HHHHHHHCCCCCCCC | 29496963 | ||
| 582 (in isoform 2) | Phosphorylation | - | 27251275 | ||
| 582 | Phosphorylation | SKLLSTYSAEELYQA HHHHHHCCHHHHHHH | 27251275 | ||
| 638 | Phosphorylation | VKGYVYSSFLKPYNP CEEEEEHHCCCCCCH | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ARH38_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ARH38_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ARH38_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CLAP1_HUMAN | CLASP1 | physical | 28514442 | |
| DMAC1_HUMAN | TMEM261 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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