dbPTM

DMAC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DMAC1_HUMAN
UniProt AC	Q96GE9
Protein Name	Distal membrane-arm assembly complex protein 1 {ECO:0000303\|PubMed:27626371}
Gene Name	DMAC1 {ECO:0000303\|PubMed:27626371, ECO:0000312\|HGNC:HGNC:30536}
Organism	Homo sapiens (Human).
Sequence Length	116
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein .
Protein Description	Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I..
Protein Sequence	MGSRLSQPFESYITAPPGTAAAPAKPAPPATPGAPTSPAEHRLLKTCWSCRVLSGLGLMGAGGYVYWVARKPMKMGYPPSPWTITQMVIGLSENQGIATWGIVVMADPKGKAYRVV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
25	Ubiquitination	GTAAAPAKPAPPATP CCCCCCCCCCCCCCC	29967540
31	Phosphorylation	AKPAPPATPGAPTSP CCCCCCCCCCCCCCH	25159151
36	Phosphorylation	PATPGAPTSPAEHRL CCCCCCCCCHHHHHH	25627689
37	Phosphorylation	ATPGAPTSPAEHRLL CCCCCCCCHHHHHHH	25849741
54	Phosphorylation	CWSCRVLSGLGLMGA HHHHHHHHCCCCCCC	29116813
64	Phosphorylation	GLMGAGGYVYWVARK CCCCCCCEEEEEECC	29116813
66	Phosphorylation	MGAGGYVYWVARKPM CCCCCEEEEEECCCC	29116813
80	Phosphorylation	MKMGYPPSPWTITQM CCCCCCCCCCCEEEE	22210691
83	Phosphorylation	GYPPSPWTITQMVIG CCCCCCCCEEEEEEE	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DMAC1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DMAC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DMAC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DMAC1_HUMAN

Related Literatures of Post-Translational Modification