ARBK1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARBK1_RAT
• UniProt AC: P26817
• Protein Name: Beta-adrenergic receptor kinase 1
• Gene Name: Grk2 {ECO:0000312|RGD:2062}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 689
• Subcellular Localization: Cytoplasm . Cell membrane .
• Protein Description: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity..
• Protein Sequence: MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFYLNHLEEAKPLVEFYEEIEKYEKLETEEERVVRSREIFDSYIMKELLACSHPFSKNATEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFHKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEIKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEDEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	ATPAARASKKILLPE CCHHHHHCCHHHCCC	29.00	20194499
466	Phosphorylation	QMVFLQKYPPPLIPP EEEEHHHCCCCCCCC	14.17	22276854
487	Phosphorylation	ADAFDIGSFDEEDTK HHCCCCCCCCCCCCC	29.83	28432305
493	Phosphorylation	GSFDEEDTKGIKLLD CCCCCCCCCCEEEEC	34.15	28551015
670	Phosphorylation	KMKNKPRSPVVELSK HHCCCCCCCCEEHHC	30.49	29779826
676	Phosphorylation	RSPVVELSKVPLIQR CCCCEEHHCCCEEEC	20.36	28432305
685	Phosphorylation	VPLIQRGSANGL--- CCEEECCCCCCC---	22.28	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
29	S	Phosphorylation	Kinase	PRKCA	P20444	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARBK1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARBK1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC5_HUMAN	HDAC5	physical	16221676
GBB1_HUMAN	GNB1	physical	16221676
AKT1_RAT	Akt1	physical	16142243

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.