AIFM3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AIFM3_HUMAN
• UniProt AC: Q96NN9
• Protein Name: Apoptosis-inducing factor 3
• Gene Name: AIFM3
• Organism: Homo sapiens (Human).
• Sequence Length: 605
• Subcellular Localization: Mitochondrion . Does not translocate to the nucleus upon induction of apoptosis.
• Protein Description: Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential..
• Protein Sequence: MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEERLSTPHPYPSPQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYVRASKQALQLQRRTKVMAKCISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSKSLDTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSSPKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFVLHSKTGDMSWLTGKGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MGGCFSKPKPVEL --CCCCCCCCCCEEE	52.72	24719451
36	Phosphorylation	LSASGKGSPRAYQGN CCCCCCCCCCCCCCC	18.07	31437759
45	Phosphorylation	RAYQGNGTARHFHTE CCCCCCCCCCCCCCC	25.23	68743731
112	Phosphorylation	LGHKCPHYGAPLVKG CCCCCCCCCCCCHHH	10.50	23607784
122	Phosphorylation	PLVKGVLSRGRVRCP CCHHHHHHCCCEECC	30.22	24719451
290	Phosphorylation	KDGFKLEYSKLLLAP ECCEEEEEEEEEECC	22.88	26074081
291	Phosphorylation	DGFKLEYSKLLLAPG CCEEEEEEEEEECCC	13.88	26074081
299	Phosphorylation	KLLLAPGSSPKTLSC EEEECCCCCCCCEEC	42.27	26074081
300	Phosphorylation	LLLAPGSSPKTLSCK EEECCCCCCCCEECC	36.01	26074081
303	Phosphorylation	APGSSPKTLSCKGKE CCCCCCCCEECCCEE	27.56	26074081
305	Phosphorylation	GSSPKTLSCKGKEVE CCCCCCEECCCEEEE	21.00	26074081
316	Phosphorylation	KEVENVFTIRTPEDA EEEEEEEEECCHHHH	12.79	26074081
352	Phosphorylation	MEVAAYLTEKAHSVS HHHHHHHHHCCCCCE	23.82	22210691
357	Phosphorylation	YLTEKAHSVSVVELE HHHHCCCCCEEEECC	22.43	22210691
366	Phosphorylation	SVVELEETPFRRFLG EEEECCCCCHHHHHH	20.53	22210691
392	Phosphorylation	ENNRVKFYMQTEVSE HCCCEEEEEEHHHHH	5.21	30624053
395	Phosphorylation	RVKFYMQTEVSELRG CEEEEEEHHHHHHCC	23.09	30624053
398	Phosphorylation	FYMQTEVSELRGQEG EEEEHHHHHHCCCCC	25.36	26270265
415	Phosphorylation	KEVVLKSSKVVRADV EEHHHHCCCCCCCCE	28.07	46160951
433	Phosphorylation	GIGAVPATGFLRQSG CCCCCCCCCHHHHCC	23.54	68710083
439	Phosphorylation	ATGFLRQSGIGLDSR CCCHHHHCCCCCCCC	26.41	68710085
445	Phosphorylation	QSGIGLDSRGFIPVN HCCCCCCCCCCEEHH	39.07	68710087
470	Phosphorylation	FAAGDAVTFPLAWRN EECCCEEEECEEECC	22.66	46160963
587 (in isoform 3)	Phosphorylation	-	4.31	-
593 (in isoform 2)	Phosphorylation	-	45.86	-
605	Phosphorylation	SWLTGKGS------- HHHCCCCC-------	40.30	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AIFM3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AIFM3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AIFM3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
FPPS_HUMAN	FDPS	physical	26344197
PPIF_HUMAN	PPIF	physical	26344197
NMT2_HUMAN	NMT2	physical	28514442
NMT1_HUMAN	NMT1	physical	28514442
PGK2_HUMAN	PGK2	physical	28514442
LZTR1_HUMAN	LZTR1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.