ACM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACM1_HUMAN
• UniProt AC: P11229
• Protein Name: Muscarinic acetylcholine receptor M1
• Gene Name: CHRM1
• Organism: Homo sapiens (Human).
• Sequence Length: 460
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
• Protein Description: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover..
• Protein Sequence: MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-linked_Glycosylation	------MNTSAPPAV ------CCCCCCCCC	42.62	UniProtKB CARBOHYD
10	Phosphorylation	TSAPPAVSPNITVLA CCCCCCCCCCEEEEC	17.84	-
12	N-linked_Glycosylation	APPAVSPNITVLAPG CCCCCCCCEEEECCC	34.75	UniProtKB CARBOHYD
49	Phosphorylation	GNLLVLISFKVNTEL CCEEEEEEEEECCCC	18.17	24719451
228	Phosphorylation	ELAALQGSETPGKGG HHHHHCCCCCCCCCC	25.90	28348404
230	Phosphorylation	AALQGSETPGKGGGS HHHCCCCCCCCCCCC	38.75	28348404
244	Phosphorylation	SSSSSERSQPGAEGS CCCCCCCCCCCCCCC	36.35	27499020
251	Phosphorylation	SQPGAEGSPETPPGR CCCCCCCCCCCCCCC	15.86	27732954
254	Phosphorylation	GAEGSPETPPGRCCR CCCCCCCCCCCCCCC	37.86	27732954
273	Phosphorylation	PRLLQAYSWKEEEEE HHHHHHHCCCCHHCC	34.39	-
315	Phosphorylation	DPEAQAPTKQPPRSS CCCCCCCCCCCCCCC	45.38	28348404
321	Phosphorylation	PTKQPPRSSPNTVKR CCCCCCCCCCCCCCC	56.79	24076635
322	Phosphorylation	TKQPPRSSPNTVKRP CCCCCCCCCCCCCCC	24.37	24076635
325	Phosphorylation	PPRSSPNTVKRPTKK CCCCCCCCCCCCCCC	30.68	28102081
332	Acetylation	TVKRPTKKGRDRAGK CCCCCCCCCCCCCCC	62.75	7370157
339	Acetylation	KGRDRAGKGQKPRGK CCCCCCCCCCCCCCH	58.12	155975
366	Phosphorylation	KEKKAARTLSAILLA HHHHHHHHHHHHHHH	21.97	-
368	Phosphorylation	KKAARTLSAILLAFI HHHHHHHHHHHHHHH	16.79	-
428	Phosphorylation	CNKAFRDTFRLLLLC HCHHHHHHHHHHHHH	13.34	-
451	Phosphorylation	KIPKRPGSVHRTPSR CCCCCCCCCCCCCCC	19.89	23403867
455	Phosphorylation	RPGSVHRTPSRQC-- CCCCCCCCCCCCC--	15.67	-
457	Phosphorylation	GSVHRTPSRQC---- CCCCCCCCCCC----	34.08	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GASP1_HUMAN	GPRASP1	physical	15086532
GASP2_HUMAN	GPRASP2	physical	15086532

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.