ACHA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACHA_MOUSE
• UniProt AC: P04756
• Protein Name: Acetylcholine receptor subunit alpha
• Gene Name: Chrna1
• Organism: Mus musculus (Mouse).
• Sequence Length: 457
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
• Protein Description: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane..
• Protein Sequence: MELSTVLLLLGLCSAGLVLGSEHETRLVAKLFEDYSSVVRPVEDHREIVQVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFAIVKFTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKEARGWKHWVFYSCCPTTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHIMPEWVRKVFIDTIPNIMFFSTMKRPSRDKQEKRIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGVKYIAETMKSDQESNNAAEEWKYVAMVMDHILLGVFMLVCLIGTLAVFAGRLIELHQQG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
124	Ubiquitination	DGDFAIVKFTKVLLD CCCEEEEEEEEEHHH	41.00	-
161	N-linked_Glycosylation	HFPFDEQNCSMKLGT ECCCCCCCCEEEEEE	20.13	17643119
369	Phosphorylation	FTEDIDISDISGKPG EECCCCHHHCCCCCC	25.74	22817900
372	Phosphorylation	DIDISDISGKPGPPP CCCHHHCCCCCCCCC	45.84	20415495

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACHA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACHA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACHA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACHA_MOUSE	Chrna1	physical	22956146
ACTN1_MOUSE	Actn1	physical	22956146

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Crystal structure of the extracellular domain of nAChR alpha1 boundto alpha-bungarotoxin at 1.94 A resolution.";
Dellisanti C.D., Yao Y., Stroud J.C., Wang Z.Z., Chen L.;
Nat. Neurosci. 10:953-962(2007).
Cited for: X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS) OF 21-231 IN COMPLEX WITHALPHA-BUNGAROTOXIN, DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-161.
PubMed: 17643119