ACBG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACBG2_HUMAN
• UniProt AC: Q5FVE4
• Protein Name: Long-chain-fatty-acid--CoA ligase ACSBG2
• Gene Name: ACSBG2
• Organism: Homo sapiens (Human).
• Sequence Length: 666
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.
• Protein Description: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis..
• Protein Sequence: MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRESVNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELYGLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMYH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	ESVNRFGTYPALASK HHHHHHCCHHHHHCC	24.50	24409183
86	Phosphorylation	EILNFNQYYEACRKA EEECHHHHHHHHHHH	12.36	22144111
87	Phosphorylation	ILNFNQYYEACRKAA EECHHHHHHHHHHHH	6.31	22144111
96	Phosphorylation	ACRKAAKSLIKLGLE HHHHHHHHHHHHCHH	30.51	24719451
169	Phosphorylation	QQLQKILSIPQSSLE HHHHHHHCCCHHHCH	35.38	24719451
184	Phosphorylation	PLKAIIQYRLPMKKN HHHHHHHCCCCCCCC	12.05	24719451
266	Phosphorylation	KLTDKHETVVSYLPL CCCCCCHHHHHHCCH	26.40	46158025
308	Phosphorylation	LKGTLVSTLKEVKPT HCCCHHHHHCHHCCE	34.08	23403867
358	Phosphorylation	NIGFKVNSKKMLGKY HCCEEECCCHHHCCC	36.32	23898821
370	Phosphorylation	GKYNTPVSYRMAKTL CCCCCCCHHHHHHHH	14.28	30631047
380	Phosphorylation	MAKTLVFSKVKTSLG HHHHHHHHHHCCCCC	29.12	30631047
541	Phosphorylation	KKKIPIISNAMLVGD CCCCCEECCCEECCH	21.18	23532336
587	Phosphorylation	NFCRGLGSQASTVTE HHHCCCCCCHHHHHH	27.84	25693802
590	Phosphorylation	RGLGSQASTVTEIVK CCCCCCHHHHHHHHH	18.77	25693802
591	Phosphorylation	GLGSQASTVTEIVKQ CCCCCHHHHHHHHHC	34.17	25693802
593	Phosphorylation	GSQASTVTEIVKQQD CCCHHHHHHHHHCCC	21.78	25693802
636	Phosphorylation	VILEKDFSIYGGELG EEEECCCEEECCCCH	25.65	30622161
657	Phosphorylation	RHFVAQKYKKQIDHM HHHHHHHHHHHHHHC	16.02	7479569
665	Phosphorylation	KKQIDHMYH------ HHHHHHCCC------	10.85	7479579

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACBG2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACBG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACBG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZZEF1_HUMAN	ZZEF1	physical	28514442
CMS1_HUMAN	CMSS1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.