ABRX2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABRX2_MOUSE
• UniProt AC: Q3TCJ1
• Protein Name: BRISC complex subunit Abraxas 2 {ECO:0000312|MGI:MGI:1926116}
• Gene Name: Abraxas2 {ECO:0000312|MGI:MGI:1926116}
• Organism: Mus musculus (Mouse).
• Sequence Length: 415
• Subcellular Localization: Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton . A minor proportion is detected in the nucleus. Translocates into the nucleus in response to DNA damage. Directly binds to microtubules and is detected at the minu
• Protein Description: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. [PubMed: 21195082 Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression]
• Protein Sequence: MAASISGYTFSAVCFHSANSNADHEGFLLGEVRQEETFSISDSQISNTEFLQVIEIHNHQPCSQLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVIHKQLTRILGVPDLVFLLFSFISTANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGTDFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQKKNEKEQERRLQQALLSRQMPSESLEPAFSPRMSYSGFSAEGRSTLAETEPSDPPPPYSDFHPNNQESTLSHSRMERSVFMPRPQAVGSSSYASTSGGLKFTGSGADLLPSQSAAGDSGEESDDSDYENLIDPAESPHSEYSHSKNSRPSTHPDEDPRNTQTSQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
187	Ubiquitination	NTSQSYAKVIKEHGT CCCHHHHHHHHHHCC		22790023
210	Phosphorylation	MKDIRAIYQVYNALQ HHHHHHHHHHHHHHH		22817900
229	Acetylation	AVCADVEKSERVVES HHHCCCHHHHHHHHH		22826441
229	Ubiquitination	AVCADVEKSERVVES HHHCCCHHHHHHHHH		22790023
237	S-nitrosocysteine	SERVVESCQAEVNKL HHHHHHHHHHHHHHH		-
272	Phosphorylation	LLSRQMPSESLEPAF HHHCCCCCCCCCCCC		25777480
274	Phosphorylation	SRQMPSESLEPAFSP HCCCCCCCCCCCCCC		25777480
280	Phosphorylation	ESLEPAFSPRMSYSG CCCCCCCCCCCCCCC		26824392
284	Phosphorylation	PAFSPRMSYSGFSAE CCCCCCCCCCCCCCC		22942356
285	Phosphorylation	AFSPRMSYSGFSAEG CCCCCCCCCCCCCCC		28833060
286	Phosphorylation	FSPRMSYSGFSAEGR CCCCCCCCCCCCCCC		28833060
289	Phosphorylation	RMSYSGFSAEGRSTL CCCCCCCCCCCCCCC		28833060
339	Phosphorylation	PRPQAVGSSSYASTS CCCCCCCCCCCEECC		29472430
340	Phosphorylation	RPQAVGSSSYASTSG CCCCCCCCCCEECCC		29472430
341	Phosphorylation	PQAVGSSSYASTSGG CCCCCCCCCEECCCC		30352176
342	Phosphorylation	QAVGSSSYASTSGGL CCCCCCCCEECCCCC		22817900
344	Phosphorylation	VGSSSYASTSGGLKF CCCCCCEECCCCCEE		29472430
345	Phosphorylation	GSSSYASTSGGLKFT CCCCCEECCCCCEEE		29472430
346	Phosphorylation	SSSYASTSGGLKFTG CCCCEECCCCCEEEC		29472430
352	Phosphorylation	TSGGLKFTGSGADLL CCCCCEEECCCCCCC		25293948
354	Phosphorylation	GGLKFTGSGADLLPS CCCEEECCCCCCCCC		25293948
361	Phosphorylation	SGADLLPSQSAAGDS CCCCCCCCCCCCCCC		25367039
363	Phosphorylation	ADLLPSQSAAGDSGE CCCCCCCCCCCCCCC		21659605
368	Phosphorylation	SQSAAGDSGEESDDS CCCCCCCCCCCCCCC		21659605
372	Phosphorylation	AGDSGEESDDSDYEN CCCCCCCCCCCCHHC		22817900
375	Phosphorylation	SGEESDDSDYENLID CCCCCCCCCHHCCCC		21659605
377	Phosphorylation	EESDDSDYENLIDPA CCCCCCCHHCCCCCC		22817900
386	Phosphorylation	NLIDPAESPHSEYSH CCCCCCCCCCCCCCC		25293948
389	Phosphorylation	DPAESPHSEYSHSKN CCCCCCCCCCCCCCC		25293948
391	Phosphorylation	AESPHSEYSHSKNSR CCCCCCCCCCCCCCC		25293948
392	Phosphorylation	ESPHSEYSHSKNSRP CCCCCCCCCCCCCCC		25293948
394	Phosphorylation	PHSEYSHSKNSRPST CCCCCCCCCCCCCCC		25293948
400	Phosphorylation	HSKNSRPSTHPDEDP CCCCCCCCCCCCCCC		23375375

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABRX2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABRX2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABRX2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATF4_MOUSE	Atf4	physical	22974638
JUND_MOUSE	Jund	physical	22974638
BRCC3_MOUSE	Brcc3	physical	22974638
ATF5_MOUSE	Atf5	physical	22974638
UBC_MOUSE	Ubc	physical	22974638

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.