ABRA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABRA_HUMAN
• UniProt AC: Q8N0Z2
• Protein Name: Actin-binding Rho-activating protein
• Gene Name: ABRA {ECO:0000312|EMBL:AAI05106.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 381
• Subcellular Localization: Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton. Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines..
• Protein Description: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling..
• Protein Sequence: MAPGEKESGEGPAKSALRKIRTATLVISLARGWQQWANENSIRQAQEPTGWLPGGTQDSPQAPKPITPPTSHQKAQSAPKSPPRLPEGHGDGQSSEKAPEVSHIKKKEVSKTVVSKTYERGGDVSHLSHRYERDAGVLEPGQPENDIDRILHSHGSPTRRRKCANLVSELTKGWRVMEQEEPTWRSDSVDTEDSGYGGEAEERPEQDGVQVAVVRIKRPLPSQVNRFTEKLNCKAQQKYSPVGNLKGRWQQWADEHIQSQKLNPFSEEFDYELAMSTRLHKGDEGYGRPKEGTKTAERAKRAEEHIYREMMDMCFIICTMARHRRDGKIQVTFGDLFDRYVRISDKVVGILMRARKHGLVDFEGEMLWQGRDDHVVITLLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAPGEKESGEGPAKS CCCCCCCCCCCCHHH	53.89	23898821
24	Phosphorylation	LRKIRTATLVISLAR HHHHHHHHHHHHHHH	22.42	46157307
28	Phosphorylation	RTATLVISLARGWQQ HHHHHHHHHHHHHHH	14.43	46157295
81	Phosphorylation	KAQSAPKSPPRLPEG HHHCCCCCCCCCCCC	38.79	22210691
94	Phosphorylation	EGHGDGQSSEKAPEV CCCCCCCCCCCCCCC	46.09	22210691
95	Phosphorylation	GHGDGQSSEKAPEVS CCCCCCCCCCCCCCC	34.92	22210691
110	Phosphorylation	HIKKKEVSKTVVSKT CCCHHHCCCEEEEEC	24.57	23403867
112	Phosphorylation	KKKEVSKTVVSKTYE CHHHCCCEEEEECEE	20.73	23403867
115	Phosphorylation	EVSKTVVSKTYERGG HCCCEEEEECEECCC	18.23	23403867
117	Phosphorylation	SKTVVSKTYERGGDV CCEEEEECEECCCCH	24.10	23403867
118	Phosphorylation	KTVVSKTYERGGDVS CEEEEECEECCCCHH	13.83	23403867
156	Phosphorylation	RILHSHGSPTRRRKC HHHHHCCCHHHHHHH	20.06	26437602
188	Phosphorylation	EPTWRSDSVDTEDSG CCCCCCCCCCCCCCC	24.12	-
259	Phosphorylation	WADEHIQSQKLNPFS HHHHHHHHCCCCCCC	28.78	30576142
266	Phosphorylation	SQKLNPFSEEFDYEL HCCCCCCCHHHCHHH	37.16	30576142
271	Phosphorylation	PFSEEFDYELAMSTR CCCHHHCHHHHHHCC	20.40	30576142
286	Phosphorylation	LHKGDEGYGRPKEGT CCCCCCCCCCCCCCC	14.12	1948195
332	Phosphorylation	RDGKIQVTFGDLFDR CCCCEEEEEHHHHHH	12.91	100646207
344	Phosphorylation	FDRYVRISDKVVGIL HHHHEEHHHHHHHHH	22.33	46157301
356	Ubiquitination	GILMRARKHGLVDFE HHHHHHHHHCCEECC	40.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABRA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABRA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABRA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTS_HUMAN	ACTA1	physical	17194709
ABLM2_HUMAN	ABLIM2	physical	17194709
ABLM3_HUMAN	ABLIM3	physical	17194709

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.