ABLM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABLM2_HUMAN
• UniProt AC: Q6H8Q1
• Protein Name: Actin-binding LIM protein 2
• Gene Name: ABLIM2
• Organism: Homo sapiens (Human).
• Sequence Length: 611
• Subcellular Localization: Cytoplasm. In skeletal muscle, sarcomeric or cosarcomeric localization..
• Protein Description: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity..
• Protein Sequence: MSAVSQPQAAPSPLEKSPSTAILCNTCGNVCKGEVLRVQDKYFHIKCFVCKACGCDLAEGGFFVRQGEYICTLDYQRLYGTRCFSCDQFIEGEVVSALGKTYHPDCFVCAVCRLPFPPGDRVTFNGKECMCQKCSLPVSVGSSAHLSQGLRSCGGCGTEIKNGQALVALDKHWHLGCFKCKSCGKLLNAEYISKDGLPYCEADYHAKFGIRCDSCEKYITGRVLEAGEKHYHPSCALCVRCGQMFAEGEEMYLQGSSIWHPACRQAARTEDRNKETRTSSESIISVPASSTSGSPSRVIYAKLGGEILDYRDLAALPKSKAIYDIDRPDMISYSPYISHSAGDRQSYGEGDQDDRSYKQCRTSSPSSTGSVSLGRYTPTSRSPQHYSRPGSESGRSTPSLSVLSDSKPPPSTYQQAPRHFHVPDTGVKDNIYRKPPIYRQHAARRSDGEDGSLDQDNRKKSSWLMLKGDADTRTNSPDLDTQSLSHSSGTDRDPLQRMAGDSFHSRFPYSKSDPLPGHGKNGLDQRNANLAPCGADPDASWGMREYKIYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKKALLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAVSQPQA ------CCCCCCCCC	37.06	28857561
12	Phosphorylation	SQPQAAPSPLEKSPS CCCCCCCCCCCCCCC	37.07	25159151
12 (in isoform 9)	Phosphorylation	-	37.07	27251275
17	Phosphorylation	APSPLEKSPSTAILC CCCCCCCCCCCEEEE	18.08	72266601
19	Phosphorylation	SPLEKSPSTAILCNT CCCCCCCCCEEEECC	37.25	25159151
19 (in isoform 9)	Phosphorylation	-	37.25	27251275
20	Phosphorylation	PLEKSPSTAILCNTC CCCCCCCCEEEECCC	22.54	28857561
75	Phosphorylation	EYICTLDYQRLYGTR EEEEEEECHHHHCCC	9.92	46157253
79	Phosphorylation	TLDYQRLYGTRCFSC EEECHHHHCCCCCCC	20.74	46157259
81	Phosphorylation	DYQRLYGTRCFSCDQ ECHHHHCCCCCCCCH	15.65	46157247
91 (in isoform 4)	Phosphorylation	-	51.06	22210691
103 (in isoform 4)	Phosphorylation	-	19.56	22210691
112 (in isoform 4)	Phosphorylation	-	1.65	24076635
114 (in isoform 4)	Phosphorylation	-	4.30	24076635
116 (in isoform 4)	Phosphorylation	-	15.70	-
135	Phosphorylation	ECMCQKCSLPVSVGS EEEEEECCCCEECCC	42.62	23312004
139	Phosphorylation	QKCSLPVSVGSSAHL EECCCCEECCCHHHH	20.86	23312004
142	Phosphorylation	SLPVSVGSSAHLSQG CCCEECCCHHHHHHC	23.38	28857561
142 (in isoform 9)	Phosphorylation	-	23.38	27251275
143	Phosphorylation	LPVSVGSSAHLSQGL CCEECCCHHHHHHCH	17.49	28857561
147	Phosphorylation	VGSSAHLSQGLRSCG CCCHHHHHHCHHHCC	16.60	23312004
276	Phosphorylation	TEDRNKETRTSSESI HCCCCCCCCCCCCCE	40.64	28857561
278	O-linked_Glycosylation	DRNKETRTSSESIIS CCCCCCCCCCCCEEE	43.98	28657654
278	Phosphorylation	DRNKETRTSSESIIS CCCCCCCCCCCCEEE	43.98	23927012
279	O-linked_Glycosylation	RNKETRTSSESIISV CCCCCCCCCCCEEEE	28.90	28657654
279	Phosphorylation	RNKETRTSSESIISV CCCCCCCCCCCEEEE	28.90	4113075
280	Phosphorylation	NKETRTSSESIISVP CCCCCCCCCCEEEEE	34.45	26657352
280 (in isoform 9)	Phosphorylation	-	34.45	27251275
282	Phosphorylation	ETRTSSESIISVPAS CCCCCCCCEEEEECC	27.46	23927012
285	Phosphorylation	TSSESIISVPASSTS CCCCCEEEEECCCCC	22.00	23927012
289	O-linked_Glycosylation	SIISVPASSTSGSPS CEEEEECCCCCCCCC	28.25	28657654
289	Phosphorylation	SIISVPASSTSGSPS CEEEEECCCCCCCCC	28.25	23663014
290	Phosphorylation	IISVPASSTSGSPSR EEEEECCCCCCCCCE	28.79	23663014
291	Phosphorylation	ISVPASSTSGSPSRV EEEECCCCCCCCCEE	34.31	23663014
292	Phosphorylation	SVPASSTSGSPSRVI EEECCCCCCCCCEEE	38.94	23927012
294	Phosphorylation	PASSTSGSPSRVIYA ECCCCCCCCCEEEEE	21.33	25159151
294 (in isoform 9)	Phosphorylation	-	21.33	24719451
296	Phosphorylation	SSTSGSPSRVIYAKL CCCCCCCCEEEEEEE	40.66	23663014
300	Phosphorylation	GSPSRVIYAKLGGEI CCCCEEEEEEECCEE	8.53	27251275
310 (in isoform 9)	Phosphorylation	-	11.55	27642862
332	Phosphorylation	IDRPDMISYSPYISH CCCCCCEEECCCCCC	16.96	18491316
332 (in isoform 9)	Phosphorylation	-	16.96	27642862
333	Phosphorylation	DRPDMISYSPYISHS CCCCCEEECCCCCCC	11.62	24076635
334	Phosphorylation	RPDMISYSPYISHSA CCCCEEECCCCCCCC	12.39	24076635
334 (in isoform 3)	Phosphorylation	-	12.39	22210691
334 (in isoform 6)	Phosphorylation	-	12.39	22210691
336 (in isoform 9)	Phosphorylation	-	14.76	27642862
338	Phosphorylation	ISYSPYISHSAGDRQ EEECCCCCCCCCCCC	12.92	28348404
338 (in isoform 9)	Phosphorylation	-	12.92	27251275
340	Phosphorylation	YSPYISHSAGDRQSY ECCCCCCCCCCCCCC	27.44	28348404
346	Phosphorylation	HSAGDRQSYGEGDQD CCCCCCCCCCCCCCC	35.68	28857561
346 (in isoform 3)	Phosphorylation	-	35.68	22210691
346 (in isoform 6)	Phosphorylation	-	35.68	22210691
355 (in isoform 3)	Phosphorylation	-	50.61	24076635
355 (in isoform 6)	Phosphorylation	-	50.61	24076635
356	Phosphorylation	EGDQDDRSYKQCRTS CCCCCCCCCCCCCCC	43.61	-
357	Phosphorylation	GDQDDRSYKQCRTSS CCCCCCCCCCCCCCC	13.13	-
357 (in isoform 3)	Phosphorylation	-	13.13	24076635
357 (in isoform 6)	Phosphorylation	-	13.13	24076635
359 (in isoform 3)	Phosphorylation	-	17.43	-
359 (in isoform 6)	Phosphorylation	-	17.43	-
362	Phosphorylation	RSYKQCRTSSPSSTG CCCCCCCCCCCCCCC	40.98	23927012
363	O-linked_Glycosylation	SYKQCRTSSPSSTGS CCCCCCCCCCCCCCC	22.39	28657654
363	Phosphorylation	SYKQCRTSSPSSTGS CCCCCCCCCCCCCCC	22.39	25159151
364	Phosphorylation	YKQCRTSSPSSTGSV CCCCCCCCCCCCCCE	28.34	28355574
364 (in isoform 9)	Phosphorylation	-	28.34	24719451
366	Phosphorylation	QCRTSSPSSTGSVSL CCCCCCCCCCCCEEE	42.34	6294607
367	Phosphorylation	CRTSSPSSTGSVSLG CCCCCCCCCCCEEEC	39.92	23927012
367 (in isoform 3)	Phosphorylation	-	39.92	-
368	Phosphorylation	RTSSPSSTGSVSLGR CCCCCCCCCCEEECC	37.50	23927012
368 (in isoform 3)	Phosphorylation	-	37.50	-
370	Phosphorylation	SSPSSTGSVSLGRYT CCCCCCCCEEECCCC	14.50	23927012
370 (in isoform 9)	Phosphorylation	-	14.50	27251275
372	Phosphorylation	PSSTGSVSLGRYTPT CCCCCCEEECCCCCC	27.14	50558825
376	Phosphorylation	GSVSLGRYTPTSRSP CCEEECCCCCCCCCC	18.44	23312004
377	Phosphorylation	SVSLGRYTPTSRSPQ CEEECCCCCCCCCCC	20.80	24719451
377 (in isoform 9)	Phosphorylation	-	20.80	24719451
379	Phosphorylation	SLGRYTPTSRSPQHY EECCCCCCCCCCCCC	29.04	23312004
380	Phosphorylation	LGRYTPTSRSPQHYS ECCCCCCCCCCCCCC	31.78	23312004
382	Phosphorylation	RYTPTSRSPQHYSRP CCCCCCCCCCCCCCC	28.78	-
382 (in isoform 7)	Phosphorylation	-	28.78	27251275
382 (in isoform 8)	Phosphorylation	-	28.78	27251275
393 (in isoform 3)	Phosphorylation	-	41.00	27251275
393 (in isoform 6)	Phosphorylation	-	41.00	27251275
396	Phosphorylation	PGSESGRSTPSLSVL CCCCCCCCCCCCCCC	48.47	26437602
397	Phosphorylation	GSESGRSTPSLSVLS CCCCCCCCCCCCCCC	18.61	26437602
399	Phosphorylation	ESGRSTPSLSVLSDS CCCCCCCCCCCCCCC	33.11	26437602
401	Phosphorylation	GRSTPSLSVLSDSKP CCCCCCCCCCCCCCC	25.91	24247654
404	Phosphorylation	TPSLSVLSDSKPPPS CCCCCCCCCCCCCCC	37.37	28787133
406	Phosphorylation	SLSVLSDSKPPPSTY CCCCCCCCCCCCCCC	43.62	28787133
425	Phosphorylation	RHFHVPDTGVKDNIY CCCCCCCCCCCCCCC	37.49	27251275
446	Phosphorylation	RQHAARRSDGEDGSL HHHCHHCCCCCCCCC	44.40	23663014
452	Phosphorylation	RSDGEDGSLDQDNRK CCCCCCCCCCCCCCC	40.89	4112367
454 (in isoform 8)	Phosphorylation	-	56.32	27251275
458 (in isoform 9)	Phosphorylation	-	56.95	27251275
461	Phosphorylation	DQDNRKKSSWLMLKG CCCCCCCCEEEEEEC	29.76	27251275
462	Phosphorylation	QDNRKKSSWLMLKGD CCCCCCCEEEEEECC	32.86	28857561
464 (in isoform 3)	Phosphorylation	-	2.88	27251275
472	Phosphorylation	MLKGDADTRTNSPDL EEECCCCCCCCCCCC	40.91	-
474	Phosphorylation	KGDADTRTNSPDLDT ECCCCCCCCCCCCCH	41.98	19764811
476	Phosphorylation	DADTRTNSPDLDTQS CCCCCCCCCCCCHHH	21.12	25159151
479 (in isoform 9)	Phosphorylation	-	9.72	24719451
481	Phosphorylation	TNSPDLDTQSLSHSS CCCCCCCHHHCCCCC	27.62	30576142
483	Phosphorylation	SPDLDTQSLSHSSGT CCCCCHHHCCCCCCC	33.65	23312004
485	Phosphorylation	DLDTQSLSHSSGTDR CCCHHHCCCCCCCCC	26.94	23312004
487	Phosphorylation	DTQSLSHSSGTDRDP CHHHCCCCCCCCCCH	27.38	30576142
488	Phosphorylation	TQSLSHSSGTDRDPL HHHCCCCCCCCCCHH	40.04	30576142
490	Phosphorylation	SLSHSSGTDRDPLQR HCCCCCCCCCCHHHH	29.79	30576142
502	Phosphorylation	LQRMAGDSFHSRFPY HHHHHCCCHHHCCCC	24.76	25159151
505	Phosphorylation	MAGDSFHSRFPYSKS HHCCCHHHCCCCCCC	33.34	30206219
505 (in isoform 2)	Phosphorylation	-	33.34	27251275
506 (in isoform 5)	Phosphorylation	-	28.17	27251275
509	Phosphorylation	SFHSRFPYSKSDPLP CHHHCCCCCCCCCCC	26.47	29116813
510	Phosphorylation	FHSRFPYSKSDPLPG HHHCCCCCCCCCCCC	26.39	30206219
510 (in isoform 9)	Phosphorylation	-	26.39	24719451
536 (in isoform 9)	Phosphorylation	-	27.22	24719451
578	Phosphorylation	TRLERHLSPEEFQEV HHHHHHCCHHHHHHH	24.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABLM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABLM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABLM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ABRA_HUMAN	ABRA	physical	17194709

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.