ABCC8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABCC8_HUMAN
• UniProt AC: Q09428
• Protein Name: ATP-binding cassette sub-family C member 8
• Gene Name: ABCC8
• Organism: Homo sapiens (Human).
• Sequence Length: 1581
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release..
• Protein Sequence: MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESHHLHLYMPAGMAFMAAVTSVVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVRADK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	N-linked_Glycosylation	LAFCGSENHSAAYRV CEECCCCCCCCCEEC	35.79	UniProtKB CARBOHYD
165	Phosphorylation	LDHAIGFSQLRFCLT HHHHCCHHHHHHHHH	24.08	24719451
302	Phosphorylation	FGRRLVLSSTFRILA HCHHHHHHHHHHHHH	21.61	24961811
528	Ubiquitination	RVETTRRKEMTSLRA HCHHHHCHHHCHHHH	48.85	-
611	Phosphorylation	LVSVQKLSEFLSSAE HHHHHHHHHHHHHHH	33.08	23898821
720	Phosphorylation	GQVGCGKSSLLLAAL EECCCCHHHHHHHHH	16.11	46156799
798	Phosphorylation	SPFNKQRYKMVIEAC CCCCHHHHHHHHHHH	10.84	71973
889	Ubiquitination	TVVLVTHKLQYLPHA EEEEEEECCCCCCCC	28.11	-
903	Ubiquitination	ADWIIAMKDGTIQRE CCEEEEECCCEEEEE	43.94	-
912	Phosphorylation	GTIQREGTLKDFQRS CEEEEECCHHHHHHH	26.36	28555341
949	Phosphorylation	TVTERKATEPPQGLS HHCCCCCCCCCCHHH	52.65	50558647
979	Phosphorylation	EEEEAAESEEDDNLS HHHHHHHCCCCCCHH	41.37	26471730
986	Phosphorylation	SEEDDNLSSMLHQRA CCCCCCHHHHHHHHC	21.69	26471730
987	Phosphorylation	EEDDNLSSMLHQRAE CCCCCHHHHHHHHCC	28.64	26471730
1049	N-linked_Glycosylation	TLTPAARNCSLSQEC CCCHHHCCCCCCCCC	18.27	UniProtKB CARBOHYD
1320	Phosphorylation	RIHGLLKTEAESYEG HHHCHHHCCHHHCCC	40.16	28450419
1324	Phosphorylation	LLKTEAESYEGLLAP HHHCCHHHCCCCCCC	35.22	28450419
1325	Phosphorylation	LKTEAESYEGLLAPS HHCCHHHCCCCCCCH	12.91	28450419
1353	Phosphorylation	IQNLSVRYDSSLKPV EEEEEEECCCCCHHH	20.30	68744609
1355	Phosphorylation	NLSVRYDSSLKPVLK EEEEECCCCCHHHHH	28.74	68744615
1356	Phosphorylation	LSVRYDSSLKPVLKH EEEECCCCCHHHHHH	37.20	68744621
1499	Phosphorylation	ARAFVRKTSIFIMDE HHHHHHHCCEEEEEC	19.25	22210691
1500	Phosphorylation	RAFVRKTSIFIMDEA HHHHHHCCEEEEECC	20.66	22210691
1510	Phosphorylation	IMDEATASIDMATEN EEECCCCCCCHHHHH	18.11	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1571	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABCC8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABCC8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPGF4_HUMAN	RAPGEF4	physical	14660679
KCJ11_HUMAN	KCNJ11	physical	12941953

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.