ABCAD_HUMAN - dbPTM
ABCAD_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABCAD_HUMAN
UniProt AC Q86UQ4
Protein Name ATP-binding cassette sub-family A member 13
Gene Name ABCA13
Organism Homo sapiens (Human).
Sequence Length 5058
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description
Protein Sequence MGHAGCQFKALLWKNWLCRLRNPVLFLAEFFWPCILFVILTVLRFQEPPRYRDICYLQPRDLPSCGVIPFVQSLLCNTGSRCRNFSYEGSMEHHFRLSRFQTAADPKKVNNLAFLKEIQDLAEEIHGMMDKAKNLKRLWVERSNTPDSSYGSSFFTMDLNKTEEVILKLESLHQQPHIWDFLLLLPRLHTSHDHVEDGMDVAVNLLQTILNSLISLEDLDWLPLNQTFSQVSELVLNVTISTLTFLQQHGVAVTEPVYHLSMQNIVWDPQKVQYDLKSQFGFDDLHTEQILNSSAELKEIPTDTSLEKMVCSVLSSTSEDEAEKWGHVGGCHPKWSEAKNYLVHAVSWLRVYQQVFVQWQQGSLLQKTLTGMGHSLEALRNQFEEESKPWKVVEALHTALLLLNDSLSADGPKDNHTFPKILQHLWKLQSLLQNLPQWPALKRFLQLDGALRNAIAQNLHFVQEVLICLETSANDFKWFELNQLKLEKDVFFWELKQMLAKNAVCPNGRFSEKEVFLPPGNSSIWGGLQGLLCYCNSSETSVLNKLLGSVEDADRILQEVITWHKNMSVLIPEEYLDWQELEMQLSEASLSCTRLFLLLGADPSPENDVFSSDCKHQLVSTVIFHTLEKTQFFLEQAYYWKAFKKFIRKTCEVAQYVNMQESFQNRLLAFPEESPCFEENMDWKMISDNYFQFLNNLLKSPTASISRALNFTKHLLMMEKKLHTLEDEQMNFLLSFVEFFEKLLLPNLFDSSIVPSFHSLPSLTEDILNISSLWTNHLKSLKRDPSATDAQKLLEFGNEVIWKMQTLGSHWIRKEPKNLLRFIELILFEINPKLLELWAYGISKGKRAKLENFFTLLNFSVPENEILSTSFNFSQLFHSDWPKSPAMNIDFVRLSEAIITSLHEFGFLEQEQISEALNTVYAIRNASDLFSALSEPQKQEVDKILTHIHLNVFQDKDSALLLQIYSSFYRYIYELLNIQSRGSSLTFLTQISKHILDIIKQFNFQNISKAFAFLFKTAEVLGGISNVSYCQQLLSIFNFLELQAQSFMSTEGQELEVIHTTLTGLKQLLIIDEDFRISLFQYMSQFFNSSVEDLLDNKCLISDNKHISSVNYSTSEESSFVFPLAQIFSNLSANVSVFNKFMSIHCTVSWLQMWTEIWETISQLFKFDMNVFTSLHHGFTQLLDELEDDVKVSKSCQGILPTHNVARLILNLFKNVTQANDFHNWEDFLDLRDFLVALGNALVSVKKLNLEQVEKSLFTMEAALHQLKTFPFNESTSREFLNSLLEVFIEFSSTSEYIVRNLDSINDFLSNNLTNYGEKFENIITELREAIVFLRNVSHDRDLFSCADIFQNVTECILEDGFLYVNTSQRMLRILDTLNSTFSSENTISSLKGCIVWLDVINHLYLLSNSSFSQGHLQNILGNFRDIENKMNSILKIVTWVLNIKKPLCSSNGSHINCVNIYLKDVTDFLNIVLTTVFEKEKKPKFEILLALLNDSTKQVRMSINNLTTDFDFASQSNWRYFTELILRPIEMSDEIPNQFQNIWLHLITLGKEFQKLVKGIYFNILENNSSSKTENLLNIFATSPKEKDVNSVGNSIYHLASYLAFSLSHDLQNSPKIIISPEIMKATGLGIQLIRDVFNSLMPVVHHTSPQNAGYMQALKKVTSVMRTLKKADIDLLVDQLEQVSVNLMDFFKNISSVGTGNLVVNLLVGLMEKFADSSHSWNVNHLLQLSRLFPKDVVDAVIDVYYVLPHAVRLLQGVPGKNITEGLKDVYSFTLLHGITISNITKEDFAIVIKILLDTIELVSDKPDIISEALACFPVVWCWNHTNSGFRQNSKIDPCNVHGLMSSSFYGKVASILDHFHLSPQGEDSPCSNESSRMEITRKVVCIIHELVDWNSILLELSEVFHVNISLVKTVQKFWHKILPFVPPSINQTRDSISELCPSGSIKQVALQIIEKLKNVNFTKVTSGENILDKLSSLNKILNINEDTETSVQNIISSNLERTVQLISEDWSLEKSTHNLLSLFMMLQNANVTGSSLEALSSFIEKSETPYNFEELWPKFQQIMKDLTQDFRIRHLLSEMNKGIKSINSMALQKITLQFAHFLEILDSPSLKTLEIIEDFLLVTKNWLQEYANEDYSRMIETLFIPVTNESSTEDIALLAKAIATFWGSLKNISRAGNFDVAFLTHLLNQEQLTNFSVVQLLFENILINLINNLAGNSQEAAWNLNDTDLQIMNFINLILNHMQSETSRKTVLSLRSIVDFTEQFLKTFFSLFLKEDSENKISLLLKYFHKDVIAEMSFVPKDKILEILKLDQFLTLMIQDRLMNIFSSLKETIYHLMKSSFILDNGEFYFDTHQGLKFMQDLFNALLRETSMKNKTENNIDFFTVVSQLFFHVNKSEDLFKLNQDLGSALHLVRECSTEMARLLDTILHSPNKDFYALYPTLQEVILANLTDLLFFINNSFPLRNRATLEITKRLVGAISRASEESHVLKPLLEMSGTLVMLLNDSADLRDLATSMDSIVKLLKLVKKVSGKMSTVFKTHFISNTKDSVKFFDTLYSIMQQSVQNLVKEIATLKKIDHFTFEKINDLLVPFLDLAFEMIGVEPYISSNSDIFSMSPSILSYMNQSKDFSDILEEIAEFLTSVKMNLEDMRSLAVAFNNETQTFSMDSVNLREEILGCLVPINNITNQMDFLYPNPISTHSGPQDIKWEIIHEVIPFLDKILSQNSTEIGSFLKMVICLTLEALWKNLKKDNWNVSNVLMTFTQHPNNLLKTIETVLEASSGIKSDYEGDLNKSLYFDTPLSQNITHHQLEKAIHNVLSRIALWRKGLLFNNSEWITSTRTLFQPLFEIFIKATTGKNVTSEKEERTKKEMIDFPYSFKPFFCLEKYLGGLFVLTKYWQQIPLTDQSVVEICEVFQQTVKPSEAMEMLQKVKMMVVRVLTIVAENPSWTKDILCATLSCKQNGIRHLILSAIQGVTLAQDHFQEIEKIWSSPNQLNCESLSKNLSSTLESFKSSLENATGQDCTSQPRLETVQQHLYMLAKSLEETWSSGNPIMTFLSNFTVTEDVKIKDLMKNITKLTEELRSSIQISNETIHSILEANISHSKVLFSALTVALSGKCDQEILHLLLTFPKGEKSWIAAEELCSLPGSKVYSLIVLLSRNLDVRAFIYKTLMPSEANGLLNSLLDIVSSLSALLAKAQHVFEYLPEFLHTFKITALLETLDFQQVSQNVQARSSAFGSFQFVMKMVCKDQASFLSDSNMFINLPRVKELLEDDKEKFNIPEDSTPFCLKLYQEILQLPNGALVWTFLKPILHGKILYTPNTPEINKVIQKANYTFYIVDKLKTLSETLLEMSSLFQRSGSGQMFNQLQEALRNKFVRNFVENQLHIDVDKLTEKLQTYGGLLDEMFNHAGAGRFRFLGSILVNLSSCVALNRFQALQSVDILETKAHELLQQNSFLASIIFSNSLFDKNFRSESVKLPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADGFKYNYVFAPLQDMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREGELEGSAPGVTLVSVTKEYEGHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLLQDSNKKSHIALGTESELQNHRPTGHLSGYCGSLARPATVQGVQLLRAQVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTPGHYQRAETYFFSSGGDNLDLTRVLLRKFRDQDLPCADLNPRQKNSSCWRTDPFSHPEFQDSCGCLKCPNRSASAPYLTNHLGHTLLNLSGFNMEEYLLAPSEKPRLGGWSFGLKIPSEAGGANGNISKPPTLAKVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYGGALLNKDKILESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFISYVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRWPRGHSTLQGTVKSSKDTDVEKEEKRVFEGRTNGDILVLYNLSKHYRRFFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKLYFPGIQFKGQHLNLLEYHVPKRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQTLQSTLDPSTDSHHTHHLPI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
102PhosphorylationFRLSRFQTAADPKKV
EECCCCCCCCCHHHC		22.5422985185
334AcetylationHVGGCHPKWSEAKNY
CCCCCCCCHHHHHHH		39.4219818069
387PhosphorylationRNQFEEESKPWKVVE
HHHHHHCCCHHHHHH		47.5021815630
406PhosphorylationALLLLNDSLSADGPK
HHHHHCCCCCCCCCC		24.1368701603
408PhosphorylationLLLNDSLSADGPKDN
HHHCCCCCCCCCCCC		28.4168701609
417PhosphorylationDGPKDNHTFPKILQH
CCCCCCCCHHHHHHH		48.1468701615
843PhosphorylationELWAYGISKGKRAKL
HHHHHCCCCCCHHHH		30.8750558383
934PhosphorylationSDLFSALSEPQKQEV
HHHHHHCCCCCHHHH		47.1246156363
971PhosphorylationIYSSFYRYIYELLNI
HHHHHHHHHHHHHCC		9.1124114839
973PhosphorylationSSFYRYIYELLNIQS
HHHHHHHHHHHCCCC		7.5024114839
1389PhosphorylationFSSENTISSLKGCIV
CCCCCHHHHHCCCHH		27.8124719451
1390PhosphorylationSSENTISSLKGCIVW
CCCCHHHHHCCCHHH		30.1924719451
1433PhosphorylationDIENKMNSILKIVTW
HHHHHHHHHHHHHHH		26.2924719451
1515PhosphorylationTTDFDFASQSNWRYF
CCCCCHHHCCCHHHH		33.8510947615
1549PhosphorylationNIWLHLITLGKEFQK
HHHHHHHHHCHHHHH		35.5046156369
1665PhosphorylationQALKKVTSVMRTLKK
HHHHHHHHHHHHHHH		19.5323532336
1669PhosphorylationKVTSVMRTLKKADID
HHHHHHHHHHHHCHH		25.4923532336
1698PhosphorylationDFFKNISSVGTGNLV
HHHHHHHCCCCCHHH		22.2919690332
1701PhosphorylationKNISSVGTGNLVVNL
HHHHCCCCCHHHHHH		22.2719690332
1773PhosphorylationTEGLKDVYSFTLLHG
CCHHHHHHHHHHCCC		14.271960199
1857PhosphorylationSFYGKVASILDHFHL
CHHHHHHHHHHHCCC		27.0346156345
1912PhosphorylationEVFHVNISLVKTVQK
HHHCCCHHHHHHHHH		23.1624719451
1966AcetylationLKNVNFTKVTSGENI
HCCCCCEECCCCCCH		39.107825287
1976AcetylationSGENILDKLSSLNKI
CCCCHHHHHHHHHHH		46.997693191
1982AcetylationDKLSSLNKILNINED
HHHHHHHHHHCCCCC		54.597693201
2084AcetylationHLLSEMNKGIKSINS
HHHHHHHHCCHHHHH		61.787971395
2256PhosphorylationTSRKTVLSLRSIVDF
CCHHHHHHHHHHHHH		19.8750558379
2290PhosphorylationKISLLLKYFHKDVIA
HHHHHHHHHCHHHHH		15.7524670416
2300PhosphorylationKDVIAEMSFVPKDKI
HHHHHHCCCCCHHHH		18.01113324625
2373PhosphorylationFNALLRETSMKNKTE
HHHHHHHHHCCCCCC		27.9029449344
2374PhosphorylationNALLRETSMKNKTEN
HHHHHHHHCCCCCCC		24.0129449344
2469MethylationNSFPLRNRATLEITK
CCCCCCCHHHHHHHH		23.63-
2483PhosphorylationKRLVGAISRASEESH
HHHHHHHHHHHHCHH		22.6646156351
2560PhosphorylationKFFDTLYSIMQQSVQ
HHHHHHHHHHHHHHH		18.0724247654
2733PhosphorylationQNSTEIGSFLKMVIC
CCCCHHHHHHHHHHH		32.8224719451
2871AcetylationEKEERTKKEMIDFPY
HHHHHHHHHHCCCCC		52.487975611
2881AcetylationIDFPYSFKPFFCLEK
CCCCCCCCCCHHHHH		34.677975619
2888AcetylationKPFFCLEKYLGGLFV
CCCHHHHHHHCCHHH		32.597975627
3057PhosphorylationSSGNPIMTFLSNFTV
HCCCCCHHHHHCCCC		23.3450558367
3060PhosphorylationNPIMTFLSNFTVTED
CCCHHHHHCCCCCCC		26.2150558387
3063PhosphorylationMTFLSNFTVTEDVKI
HHHHHCCCCCCCCCH		30.6750558399
3138PhosphorylationTFPKGEKSWIAAEEL
HCCCCCCEEEHHHHH		21.2950558373
3147PhosphorylationIAAEELCSLPGSKVY
EHHHHHHCCCCCHHH		50.6650558393
3151PhosphorylationELCSLPGSKVYSLIV
HHHCCCCCHHHHHHH		19.6027732954
3477PhosphorylationDKNFRSESVKLPPHV
CCCCCCCCCCCCCCC		26.2928176443
3487PhosphorylationLPPHVSYTIRTNVLY
CCCCCEEEEECCEEE		9.1124719451
3520PhosphorylationLPADGFKYNYVFAPL
CCCCCCCCCEEEECH		14.957343089
3522PhosphorylationADGFKYNYVFAPLQD
CCCCCCCEEEECHHH		8.217343099
3590AcetylationSVASMVRKLVYEQEI
HHHHHHHHHHHHCCC		30.7827452117
3843PhosphorylationEGSAPGVTLVSVTKE
CCCCCCEEEEEEECC		27.6223882029
3846PhosphorylationAPGVTLVSVTKEYEG
CCCEEEEEEECCCCC		27.4723312004
3848PhosphorylationGVTLVSVTKEYEGHK
CEEEEEEECCCCCCE		15.6223312004
3866PhosphorylationQDLSLTFYRDQITAL
EEEEEEEEHHHHHHH		14.1925884760
3886PhosphorylationAGKTTIISMLTGLHP
CCHHHHHHHCCCCCC		12.1422210691
3889PhosphorylationTTIISMLTGLHPPTS
HHHHHHCCCCCCCCC		29.1122210691
3896PhosphorylationTGLHPPTSGTIIING
CCCCCCCCCEEEECC		39.4522210691
4093PhosphorylationKDMACVTSLIKIYIP
CHHHHHHHHHHHHCC		14.0124719451
4225PhosphorylationRTLRAGKSTLADLLL
HHHHCCCCHHHHHHH		27.9522210691
4226PhosphorylationTLRAGKSTLADLLLP
HHHCCCCHHHHHHHH		29.4722210691
4259PhosphorylationEYPPLRLTPGHYQRA
CCCCCCCCCCCHHHC		22.3122210691
4263PhosphorylationLRLTPGHYQRAETYF
CCCCCCCHHHCEEEE		12.9522210691
4273PhosphorylationAETYFFSSGGDNLDL
CEEEEECCCCCCCCH		41.4650558361
4539O-linked_GlycosylationFRKNLAATALLLSLF
HCHHHHHHHHHHHHH		16.5429351928
4544O-linked_GlycosylationAATALLLSLFGYATL
HHHHHHHHHHHHHHH		22.9429351928
4550O-linked_GlycosylationLSLFGYATLPWMYLM
HHHHHHHHHHHHHHH		25.5229351928
4558O-linked_GlycosylationLPWMYLMSRIFSSSD
HHHHHHHHHHHCCCC		21.4529351928
4605PhosphorylationAKNLQNIYDVLKWVF
HCCHHHHHHHHHHHH		13.937348355
4824PhosphorylationEHLYYYCSLRGIPRQ
HHHHHHHHHCCCCHH		12.6546156357
4935AcetylationIMVNGSFKCLGSPQH
HHHCCCEEECCCHHH		30.1911790837
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABCAD_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABCAD_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABCAD_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
APOA1_HUMANAPOA1physical
11162594
APOA2_HUMANAPOA2physical
11162594
GLO2_HUMANHAGHphysical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABCAD_HUMAN

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Related Literatures of Post-Translational Modification

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