ABCA5_HUMAN - dbPTM
ABCA5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABCA5_HUMAN
UniProt AC Q8WWZ7
Protein Name ATP-binding cassette sub-family A member 5
Gene Name ABCA5
Organism Homo sapiens (Human).
Sequence Length 1642
Subcellular Localization Lysosome membrane
Multi-pass membrane protein. Late endosome membrane
Multi-pass membrane protein. Golgi apparatus membrane
Multi-pass membrane protein.
Protein Description May play a role in the processing of autolysosomes..
Protein Sequence MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLNSTLWWERTQEDRVVF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationRTLLLKNYLIKCRTK
HHHHHHHHHHHHCCC		14.2818083107
58PhosphorylationMMHPNKKYEEVPNIE
HHCCCCCCCCCCCCC		20.9418083107
86N-linked_GlycosylationLGYTPVTNITSSIMQ
CCCCCCCCCCHHHHH		35.46UniProtKB CARBOHYD
134PhosphorylationVGVVFKDSMSYELRF
EEEEEECCCCEEEEC		15.3723663014
136PhosphorylationVVFKDSMSYELRFFP
EEEECCCCEEEECCC		21.2923663014
137PhosphorylationVFKDSMSYELRFFPD
EEECCCCEEEECCCC		15.4423663014
149PhosphorylationFPDMIPVSSIYMDSR
CCCCCCHHHEEECCC		12.9823663014
150PhosphorylationPDMIPVSSIYMDSRA
CCCCCHHHEEECCCC		20.2623663014
152PhosphorylationMIPVSSIYMDSRAGC
CCCHHHEEECCCCCC		9.2323663014
155PhosphorylationVSSIYMDSRAGCSKS
HHHEEECCCCCCCCC		13.9023663014
192PhosphorylationIQLKTNVSLWKELES
HHHHHCHHHHHHHHH		30.4946156531
208PhosphorylationKAVIMGETAVVEIDT
CEEEECCEEEEEEEC		21.0123898821
218MethylationVEIDTFPRGVILIYL
EEEECCCCHHHHEEH		48.06-
458N-linked_GlycosylationSEGNVNGNISFSEII
CCCCCCCCCCHHHHC		22.87UniProtKB CARBOHYD
462PhosphorylationVNGNISFSEIIEPVS
CCCCCCHHHHCCCCC		22.5426657352
469PhosphorylationSEIIEPVSSEFVGKE
HHHCCCCCCHHCCHH		34.5626657352
470PhosphorylationEIIEPVSSEFVGKEA
HHCCCCCCHHCCHHH		34.9826657352
490UbiquitinationIQKTYRKKGENVEAL
CHHHHHHCCCCHHHH		63.5629967540
546PhosphorylationSIYGHRVSEIDEMFE
HHHCCCHHHHHHHHH		28.8825693802
608UbiquitinationDLDMQTIKDNQAKKL
CCCCHHHCCCCCHHC		54.7529967540
614AcetylationIKDNQAKKLSGGQKR
HCCCCCHHCCCCCCC		51.40130299
616PhosphorylationDNQAKKLSGGQKRKL
CCCCHHCCCCCCCEE		50.1646156537
620AcetylationKKLSGGQKRKLSLGI
HHCCCCCCCEEEEEE		55.57130303
624PhosphorylationGGQKRKLSLGIAVLG
CCCCCEEEEEEEECC		27.8245666001
642PhosphorylationILLLDEPTAGMDPCS
EEEECCCCCCCCHHH		33.5245666007
649PhosphorylationTAGMDPCSRHIVWNL
CCCCCHHHHHHHHHH		32.0845666013
666PhosphorylationYRKANRVTVFSTHFM
HHHHCCEEEEECCCC		16.7626552605
669PhosphorylationANRVTVFSTHFMDEA
HCCEEEEECCCCCHH		19.3526552605
670PhosphorylationNRVTVFSTHFMDEAD
CCEEEEECCCCCHHH		13.9926552605
683MethylationADILADRKAVISQGM
HHHHHCHHHHHCCCH		47.77-
683TrimethylationADILADRKAVISQGM
HHHHHCHHHHHCCCH		47.77-
687PhosphorylationADRKAVISQGMLKCV
HCHHHHHCCCHHHHH		17.6826552605
701UbiquitinationVGSSMFLKSKWGIGY
HHCCHHHHHCCCCCH		38.43-
703UbiquitinationSSMFLKSKWGIGYRL
CCHHHHHCCCCCHHH		48.10-
815PhosphorylationEEEMDSKSFDEMEQS
HHHCCCCCHHHHHHH		41.7129507054
827PhosphorylationEQSLLILSETKAALV
HHHHHHHHHHHHHHH		35.9023532336
854PhosphorylationIAKFHFFTLKRESKS
HHHEEEECCCCCCHH		30.35108417635
859PhosphorylationFFTLKRESKSVRSVL
EECCCCCCHHHHHHH		33.9746156549
910UbiquitinationKPGDKPHKYKTSLLL
CCCCCCCCCCCHHHC		57.9029967540
996N-linked_GlycosylationNYYLYHLNVTETIQI
CEEEECCCCCCEEEE		25.92UniProtKB CARBOHYD
1050UbiquitinationNAENHKIKAYTQLKL
CCCCCCCEEEHHHHH		39.8929967540
1185PhosphorylationPLLGCLISFIKISWK
HHHHHHHHHHHCHHH		14.1524719451
1254UbiquitinationSTKSKNRKLPEPPDN
CCCCCCCCCCCCCCC		77.2129967540
1299PhosphorylationVSNLHKEYDDKKDFL
EEECCHHHCCHHHHH		33.96119433
1302UbiquitinationLHKEYDDKKDFLLSR
CCHHHCCHHHHHHHH		51.8829967540
1303UbiquitinationHKEYDDKKDFLLSRK
CHHHCCHHHHHHHHH		61.7929967540
1405PhosphorylationYGAVKGMSASDMKEV
HHHHCCCCHHHHHHH		33.0346156513
1407PhosphorylationAVKGMSASDMKEVIS
HHCCCCHHHHHHHHH		30.8246156519
1410UbiquitinationGMSASDMKEVISRIT
CCCHHHHHHHHHHHH		54.5432015554
1414PhosphorylationSDMKEVISRITHALD
HHHHHHHHHHHHHHH		23.8623403867
1417PhosphorylationKEVISRITHALDLKE
HHHHHHHHHHHHHHH		10.4523403867
1423UbiquitinationITHALDLKEHLQKTV
HHHHHHHHHHHHHHH		42.6329967540
1428UbiquitinationDLKEHLQKTVKKLPA
HHHHHHHHHHHHCCH		62.7429967540
1562PhosphorylationPNASRQESFSSILAY
CCCCCCCCHHHHHCC		23.3028450419
1564PhosphorylationASRQESFSSILAYKI
CCCCCCHHHHHCCCC		26.2550558459
1565PhosphorylationSRQESFSSILAYKIP
CCCCCHHHHHCCCCC		21.4428450419
1569PhosphorylationSFSSILAYKIPKEDV
CHHHHHCCCCCHHHH		13.1528450419
1585UbiquitinationSLSQSFFKLEEAKHA
HHHHHHHHHHHHHHH		53.6429967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABCA5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABCA5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABCA5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CP2E1_HUMANCYP2E1physical
21988832
NR4A1_HUMANNR4A1physical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00864Tacrolimus
Regulatory Network of ABCA5_HUMAN

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Related Literatures of Post-Translational Modification

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