| UniProt ID | 5HT3D_HUMAN | |
|---|---|---|
| UniProt AC | Q70Z44 | |
| Protein Name | 5-hydroxytryptamine receptor 3D | |
| Gene Name | HTR3D | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 454 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. |
|
| Protein Description | This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.. | |
| Protein Sequence | MQKHSPGPPALALLSQSLLTTGNGDTLIINCPGFGQHRVDPAAFQAVFDRKAIGPVTNYSVATHVNISFTLSAIWNCYSRIHTFNCHHARPWHNQFVQWNPDECGGIKKSGMATENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRARAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVAPLALMQTPLPAGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 | Phosphorylation | LLSQSLLTTGNGDTL HHHHHHHHCCCCCEE | 37.64 | 22798277 | |
| 32 (in isoform 2) | Phosphorylation | - | 36.34 | 22210691 | |
| 66 | N-linked_Glycosylation | YSVATHVNISFTLSA CEEEEEECEEEHHHH | 19.31 | UniProtKB CARBOHYD | |
| 87 (in isoform 4) | Phosphorylation | - | 20.81 | 22210691 | |
| 89 (in isoform 4) | Phosphorylation | - | 8.79 | 22210691 | |
| 94 (in isoform 4) | Phosphorylation | - | 32.87 | 22798277 | |
| 96 (in isoform 4) | Phosphorylation | - | 5.53 | 22798277 | |
| 102 (in isoform 4) | Phosphorylation | - | 61.68 | 22798277 | |
| 106 (in isoform 4) | Phosphorylation | - | 39.95 | 22210691 | |
| 115 (in isoform 4) | Phosphorylation | - | 40.56 | 28796482 | |
| 118 (in isoform 4) | Phosphorylation | - | 12.85 | 28796482 | |
| 120 | Phosphorylation | ATENLWLSDVFIEES CCCCEEECEEEEECC | 21.83 | - | |
| 120 (in isoform 4) | Phosphorylation | - | 21.83 | 28796482 | |
| 123 (in isoform 4) | Phosphorylation | - | 7.55 | 28796482 | |
| 138 | Phosphorylation | TPAGLMASMSIVKAT CCCHHHHHHHHHHHC | 10.09 | 46155821 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of 5HT3D_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of 5HT3D_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of 5HT3D_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| LRFN4_HUMAN | LRFN4 | physical | 28514442 | |
| RSPRY_HUMAN | RSPRY1 | physical | 28514442 | |
| HSDL1_HUMAN | HSDL1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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