5HT2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 5HT2A_HUMAN
• UniProt AC: P28223
• Protein Name: 5-hydroxytryptamine receptor 2A
• Gene Name: HTR2A
• Organism: Homo sapiens (Human).
• Sequence Length: 471
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell projection, dendrite. Cell projection, axon . Cytoplasmic vesicle . Membrane, caveola . Localizes to the postsynaptic thickening of axo-dendritic synapses..
• Protein Description: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). [PubMed: 1330647]
• Protein Sequence: MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	N-linked_Glycosylation	MDILCEENTSLSSTT CCCCCCCCCCCCCCC	16.81	UniProtKB CARBOHYD
9	Phosphorylation	DILCEENTSLSSTTN CCCCCCCCCCCCCCC	34.03	20639409
10	Phosphorylation	ILCEENTSLSSTTNS CCCCCCCCCCCCCCC	37.52	20639409
12	Phosphorylation	CEENTSLSSTTNSLM CCCCCCCCCCCCCHH	25.96	20639409
13	Phosphorylation	EENTSLSSTTNSLMQ CCCCCCCCCCCCHHC	44.54	20639409
14	Phosphorylation	ENTSLSSTTNSLMQL CCCCCCCCCCCHHCC	26.99	20639409
15	Phosphorylation	NTSLSSTTNSLMQLN CCCCCCCCCCHHCCC	25.43	20639409
17	Phosphorylation	SLSSTTNSLMQLNDD CCCCCCCCHHCCCCC	24.11	20639409
25	Phosphorylation	LMQLNDDTRLYSNDF HHCCCCCCCEECCCC	25.99	20639409
38	N-linked_Glycosylation	DFNSGEANTSDAFNW CCCCCCCCCCCCCCC	35.49	UniProtKB CARBOHYD
44	N-linked_Glycosylation	ANTSDAFNWTVDSEN CCCCCCCCCEECCCC	34.92	UniProtKB CARBOHYD
51	N-linked_Glycosylation	NWTVDSENRTNLSCE CCEECCCCCCCCCCC	61.09	UniProtKB CARBOHYD
54	N-linked_Glycosylation	VDSENRTNLSCEGCL ECCCCCCCCCCCCEE	27.07	UniProtKB CARBOHYD
145	Phosphorylation	GYRWPLPSKLCAVWI CCCCCCCHHHHHHHH	46.04	24719451
280	Phosphorylation	GTRAKLASFSFLPQS CHHHHHHHHCCCCCC	31.68	14988405
287	Phosphorylation	SFSFLPQSSLSSEKL HHCCCCCCCCCHHHH	31.16	64010021
288	Phosphorylation	FSFLPQSSLSSEKLF HCCCCCCCCCHHHHH	27.33	64010023
290	Phosphorylation	FLPQSSLSSEKLFQR CCCCCCCCHHHHHHH	38.10	64010025
291	Phosphorylation	LPQSSLSSEKLFQRS CCCCCCCHHHHHHHH	44.00	64010029
298	Phosphorylation	SEKLFQRSIHREPGS HHHHHHHHHCCCCCC	16.38	55443837
305	Phosphorylation	SIHREPGSYTGRRTM HHCCCCCCCCCCCHH	30.18	64010027
419	Phosphorylation	NTIPALAYKSSQLQM ECHHHHHHHHHHHHH	16.56	80514403

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 5HT2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 5HT2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 5HT2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLG4_HUMAN	DLG4	physical	12682061
CBL_HUMAN	CBL	physical	21464131
ARF6_HUMAN	ARF6	physical	16545942
ARF1_HUMAN	ARF1	physical	16545942

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.