5HT1D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 5HT1D_HUMAN
• UniProt AC: P28221
• Protein Name: 5-hydroxytryptamine receptor 1D
• Gene Name: HTR1D
• Organism: Homo sapiens (Human).
• Sequence Length: 377
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction..
• Protein Sequence: MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	N-linked_Glycosylation	---MSPLNQSAEGLP ---CCCCCCCCCCCC	36.83	UniProtKB CARBOHYD
17	N-linked_Glycosylation	GLPQEASNRSLNATE CCCHHHHHCCCCCCC	44.61	UniProtKB CARBOHYD
21	N-linked_Glycosylation	EASNRSLNATETSEA HHHHCCCCCCCCCCC	46.17	UniProtKB CARBOHYD
61	Phosphorylation	LSNAFVLTTILLTRK HHHHHHHHHHHHHCC	13.39	30814435
137	Phosphorylation	CVIALDRYWAITDAL HHHHHHHHHHHHHHH	10.00	50558095
147	Phosphorylation	ITDALEYSKRRTAGH HHHHHHHHHHCCHHH	15.43	50558103
193	Phosphorylation	SDCLVNTSQISYTIY HHCCCCCHHCCCHHH	21.95	46155767
233	Phosphorylation	NRILNPPSLYGKRFT CCCCCCHHHCCCCCE	35.17	26546556
235	Phosphorylation	ILNPPSLYGKRFTTA CCCCHHHCCCCCEEE	25.57	11926515
280	Ubiquitination	FFNHVKIKLADSALE CCCHHHHHHCHHHHH	31.72	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 5HT1D_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 5HT1D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 5HT1D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S1PR1_HUMAN	S1PR1	physical	11854302
5HT1B_HUMAN	HTR1B	physical	11854302

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.