5HT1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 5HT1B_HUMAN
• UniProt AC: P28222
• Protein Name: 5-hydroxytryptamine receptor 1B
• Gene Name: HTR1B
• Organism: Homo sapiens (Human).
• Sequence Length: 390
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries..
• Protein Sequence: MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	N-linked_Glycosylation	ETWVPQANLSSAPSQ CCCCCCCCCCCCCCC	34.90	UniProtKB CARBOHYD
32	N-linked_Glycosylation	LSSAPSQNCSAKDYI CCCCCCCCCCCCCCC	26.50	UniProtKB CARBOHYD
60	Phosphorylation	VMLLALITLATTLSN HHHHHHHHHHHHHHH	15.93	50558087
63	Phosphorylation	LALITLATTLSNAFV HHHHHHHHHHHHHHH	31.23	68738955
64	Phosphorylation	ALITLATTLSNAFVI HHHHHHHHHHHHHHH	23.68	68738961
265	O-linked_Glycosylation	TDSPGSTSSVTSINS ECCCCCCCCCEECCC	25.22	OGP
279	Phosphorylation	SRVPDVPSESGSPVY CCCCCCCCCCCCCEE	44.22	27732954
281	Phosphorylation	VPDVPSESGSPVYVN CCCCCCCCCCCEEEE	49.24	27732954
283	Phosphorylation	DVPSESGSPVYVNQV CCCCCCCCCEEEEEE	22.07	27732954
295	Phosphorylation	NQVKVRVSDALLEKK EEEEEEHHHHHHHHH	13.45	23403867
388	S-palmitoylation	HKLIRFKCTS----- HHHHHHHCCC-----	4.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 5HT1B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 5HT1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 5HT1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDFI_HUMAN	MDFI	physical	24722188
MDFI_HUMAN	MDFI	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.