ZSCA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZSCA4_HUMAN
• UniProt AC: Q8NAM6
• Protein Name: Zinc finger and SCAN domain-containing protein 4
• Gene Name: ZSCAN4
• Organism: Homo sapiens (Human).
• Sequence Length: 433
• Subcellular Localization: Nucleus . Chromosome, telomere.
• Protein Description: Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity)..
• Protein Sequence: MALDLRTIFQCEPSENNLGSENSAFQQSQGPAVQREEGISEFSRMVLNSFQDSNNSYARQELQRLYRIFHSWLQPEKHSKDEIISLLVLEQFMIGGHCNDKASVKEKWKSSGKNLERFIEDLTDDSINPPALVHVHMQGQEALFSEDMPLRDVIVHLTKQVNAQTTREANMGTPSQTSQDTSLETGQGYEDEQDGWNSSSKTTRVNENITNQGNQIVSLIIIQEENGPRPEEGGVSSDNPYNSKRAELVTARSQEGSINGITFQGVPMVMGAGCISQPEQSSPESALTHQSNEGNSTCEVHQKGSHGVQKSYKCEECPKVFKYLCHLLAHQRRHRNERPFVCPECQKGFFQISDLRVHQIIHTGKKPFTCSMCKKSFSHKTNLRSHERIHTGEKPYTCPFCKTSYRQSSTYHRHMRTHEKITLPSVPSTPEAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	Phosphorylation	SVKEKWKSSGKNLER HHHHHHHHCCCCHHH	43.11	29449344
111	Phosphorylation	VKEKWKSSGKNLERF HHHHHHHCCCCHHHH	50.49	29449344
198	Phosphorylation	DEQDGWNSSSKTTRV CCCCCCCCCCCCEEE	29.49	22210691
202	Phosphorylation	GWNSSSKTTRVNENI CCCCCCCCEEECCCC	23.06	22210691
250	Phosphorylation	SKRAELVTARSQEGS CCCEEEEEECCCCCC	29.04	24732914
353	Phosphorylation	QKGFFQISDLRVHQI CCCEEEEHHEEEEEE	21.58	24719451
391	Phosphorylation	RSHERIHTGEKPYTC CCCCCCCCCCCCCCC	44.67	28111955
417	Phosphorylation	TYHRHMRTHEKITLP CHHHCCCCCCCEECC	27.15	-
422	Phosphorylation	MRTHEKITLPSVPST CCCCCCEECCCCCCC	43.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZSCA4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZSCA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZSCA4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZSCA4_HUMAN	ZSCAN4	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.