ZRAN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZRAN1_MOUSE
• UniProt AC: Q7M760
• Protein Name: Ubiquitin thioesterase Zranb1
• Gene Name: Zranb1
• Organism: Mus musculus (Mouse).
• Sequence Length: 708
• Subcellular Localization: Cytoplasm. Nucleus. Enriched in punctate localization in the cytoplasm..
• Protein Description: Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling (By similarity)..
• Protein Sequence: MSEHGIKWACEYCTYENWPSAIKCTMCRAQRPSGTIITEDPFKSGSSDVGRDWDPSSTEGGSSPLICPDSSARPRVKSSYSMENANKWSCHMCTYLNWPRAIRCTQCLSQRRTRSPTESPQSSGSGSRPVAFSVDPCEEYNDRNKLNTRTQHWTCSVCTYENWAKAKKCVVCDHPRPNNIEAIELAETEEASSIINEQDRARWRGGCSSGNSQRRSPPTTKRDSEVKMDFQRIELAGAVGTKEELEVDFKKLKQIKNRMKKTDWLFLNACVGVVEGDLAAIEAYKSSGGDIARQLTADEVRLLNRPSAFDVGYTLVHLAIRFQRQDMLAILLTEVSQQAAKCIPAMVCPELTEQIRREIAASLHQRKGDFACYFLTDLVTFTLPADIEDLPPTVQEKLFDEVLDRDVQKELEEESPIINWSLELATRLDSRLYALWNRTAGDCLLDSVLQATWGIYDKDSVLRKALHDSLHDCSHWFYTRWKDWESWYSQSFGLHFSLREEQWQEDWAFILSLASQPGASLEQTHIFVLAHILRRPIIVYGVKYYKSFRGETLGYTRFQGVYLPLLWEQSFCWKSPIALGYTRGHFSALVAMENDGYGNRGAGANLNTDDDVTITFLPLVDSERKLLHVHFLSAQELGNEEQQEKLLREWLDCCVTEGGVLVAMQKSSRRRNHPLVTQMVEKWLDRYRQIRPCTSLSDGEEDEDDEDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Phosphorylation	PRVKSSYSMENANKW CCCCCCCCCCCCCCC	22.90	28464351
113	Phosphorylation	QCLSQRRTRSPTESP HHHHHCCCCCCCCCC	37.37	29899451
220	Ubiquitination	QRRSPPTTKRDSEVK CCCCCCCCCCCCCCC	29.83	27667366
546	Ubiquitination	VYGVKYYKSFRGETL EEEEEEEHHHCCCCC	39.77	27667366
552	Phosphorylation	YKSFRGETLGYTRFQ EHHHCCCCCCEEEEE	28.45	24719451
572	Ubiquitination	LLWEQSFCWKSPIAL EEEECEECCCCCEEC	5.61	27667366
575	Phosphorylation	EQSFCWKSPIALGYT ECEECCCCCEECCCC	9.31	28418008
694	Phosphorylation	YRQIRPCTSLSDGEE HHHHCCCCCCCCCCC	35.07	30635358
695	Phosphorylation	RQIRPCTSLSDGEED HHHCCCCCCCCCCCC	32.37	30635358
697	Phosphorylation	IRPCTSLSDGEEDED HCCCCCCCCCCCCCC	43.25	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZRAN1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZRAN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZRAN1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APC_HUMAN	APC	physical	18281465

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.