ZNF10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZNF10_HUMAN
• UniProt AC: P21506
• Protein Name: Zinc finger protein 10
• Gene Name: ZNF10
• Organism: Homo sapiens (Human).
• Sequence Length: 573
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MDAKSLTAWSRTLVTFKDVFVDFTREEWKLLDTAQQIVYRNVMLENYKNLVSLGYQLTKPDVILRLEKGEEPWLVEREIHQETHPDSETAFEIKSSVSSRSIFKDKQSCDIKMEGMARNDLWYLSLEEVWKCRDQLDKYQENPERHLRQVAFTQKKVLTQERVSESGKYGGNCLLPAQLVLREYFHKRDSHTKSLKHDLVLNGHQDSCASNSNECGQTFCQNIHLIQFARTHTGDKSYKCPDNDNSLTHGSSLGISKGIHREKPYECKECGKFFSWRSNLTRHQLIHTGEKPYECKECGKSFSRSSHLIGHQKTHTGEEPYECKECGKSFSWFSHLVTHQRTHTGDKLYTCNQCGKSFVHSSRLIRHQRTHTGEKPYECPECGKSFRQSTHLILHQRTHVRVRPYECNECGKSYSQRSHLVVHHRIHTGLKPFECKDCGKCFSRSSHLYSHQRTHTGEKPYECHDCGKSFSQSSALIVHQRIHTGEKPYECCQCGKAFIRKNDLIKHQRIHVGEETYKCNQCGIIFSQNSPFIVHQIAHTGEQFLTCNQCGTALVNTSNLIGYQTNHIRENAY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MDAKSLTAWSRT ---CCHHHHHHHHHH	32.45	30622161
7	Phosphorylation	-MDAKSLTAWSRTLV -CCHHHHHHHHHHEE	32.92	30622161
10	Phosphorylation	AKSLTAWSRTLVTFK HHHHHHHHHHEEEEH	16.96	30622161
12	Phosphorylation	SLTAWSRTLVTFKDV HHHHHHHHEEEEHHH	21.77	30622161
15	Phosphorylation	AWSRTLVTFKDVFVD HHHHHEEEEHHHHCC	28.25	30622161
68	Ubiquitination	DVILRLEKGEEPWLV CEEEEECCCCCCEEE	75.98	-
101	Phosphorylation	KSSVSSRSIFKDKQS ECCCCCCCCCCCCCC	34.03	24719451
159	Phosphorylation	FTQKKVLTQERVSES HHHHHEEEHHHHCCC	31.22	23532336
268	Sumoylation	REKPYECKECGKFFS CCCCCCCCCCCCEEE	44.06	-
268	Sumoylation	REKPYECKECGKFFS CCCCCCCCCCCCEEE	44.06	-
288	Phosphorylation	TRHQLIHTGEKPYEC CHHHEEECCCCCCCC	39.79	29496963
296	Sumoylation	GEKPYECKECGKSFS CCCCCCCCCCCCCCC	44.06	-
296	Sumoylation	GEKPYECKECGKSFS CCCCCCCCCCCCCCC	44.06	-
303	Phosphorylation	KECGKSFSRSSHLIG CCCCCCCCCCCCCCC	38.04	17081983
324	Sumoylation	GEEPYECKECGKSFS CCCCEECCCCCCCCC	44.06	-
324	Sumoylation	GEEPYECKECGKSFS CCCCEECCCCCCCCC	44.06	-
342	Phosphorylation	HLVTHQRTHTGDKLY HHHHCCCCCCCCCEE	19.74	21082442
344	Phosphorylation	VTHQRTHTGDKLYTC HHCCCCCCCCCEEEE	46.60	21082442
350	Phosphorylation	HTGDKLYTCNQCGKS CCCCCEEEECCCCCC	18.54	21082442
370	Phosphorylation	RLIRHQRTHTGEKPY HHHCCCCCCCCCCCC	19.74	-
372	Phosphorylation	IRHQRTHTGEKPYEC HCCCCCCCCCCCCCC	46.56	-
454	Phosphorylation	HLYSHQRTHTGEKPY CHHCCCCCCCCCCCE	19.74	-
456	Phosphorylation	YSHQRTHTGEKPYEC HCCCCCCCCCCCEEC	46.56	-
484	Phosphorylation	IVHQRIHTGEKPYEC EEEEEECCCCCCCCC	44.67	28111955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZNF10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZNF10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZNF10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIF1B_HUMAN	TRIM28	physical	9016654
TIF1A_HUMAN	TRIM24	physical	9016654
TIF1B_HUMAN	TRIM28	physical	10748030
TIF1B_HUMAN	TRIM28	physical	20176155
CBX3_HUMAN	CBX3	physical	20176155
TIF1B_HUMAN	TRIM28	physical	21170338
ZN274_HUMAN	ZNF274	physical	17512541
TIF1B_HUMAN	TRIM28	physical	17512541
TIF1B_HUMAN	TRIM28	physical	8769649
TIF1B_HUMAN	TRIM28	physical	10653693
TIF1B_MOUSE	Trim28	physical	16904636

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.