ZN586_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN586_HUMAN
• UniProt AC: Q9NXT0
• Protein Name: Zinc finger protein 586
• Gene Name: ZNF586
• Organism: Homo sapiens (Human).
• Sequence Length: 402
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEAQRCLYRDVMLETLTLISSLGCWHGGEDEAAPSKQSTCIHIYKDQGGHSGERPYECGEYRKLFKNKSCLTEPRRDHKHRNVRTGERPYECSKYGKLFHQKPTLHIHERFHTGQKTYECSECGKSFHQSSSLLQRQTLHTRERPYECIECGKAFAEKSSLINHRKVHSGAKRYECNECGKSFAYTSSLIKHRRIHTGERPYECSECGRSFAENSSLIKHLRVHTGERPYECVECGKSFRRSSSLLQHQRVHTRERPYECSECGKSFSLRSNLIHHQRVHTGERHECGQCGKSFSRKSSLIIHLRVHTGERPYECSDCGKSFAENSSLIKHLRVHTGERPYECIDCGKSFRHSSSFRRHQRVHTGMRPYK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88 (in isoform 2)	Phosphorylation	-	30.03	24626860
90 (in isoform 2)	Phosphorylation	-	4.07	24626860
206	Phosphorylation	VHSGAKRYECNECGK CCCCCCEEECCCCCC	24.91	-
208	Ubiquitination	SGAKRYECNECGKSF CCCCEEECCCCCCCE	3.73	21890473
220	Phosphorylation	KSFAYTSSLIKHRRI CCEEEHHHHHHCCCC	26.72	24719451
229	Phosphorylation	IKHRRIHTGERPYEC HHCCCCCCCCCCCCC	38.06	-
248	Phosphorylation	RSFAENSSLIKHLRV CCHHHCCHHHEEEEE	45.77	24719451
251	Sumoylation	AENSSLIKHLRVHTG HHCCHHHEEEEECCC	41.71	-
251	Ubiquitination	AENSSLIKHLRVHTG HHCCHHHEEEEECCC	41.71	21890473
251	Sumoylation	AENSSLIKHLRVHTG HHCCHHHEEEEECCC	41.71	-
257	Phosphorylation	IKHLRVHTGERPYEC HEEEEECCCCCCEEH	37.57	21712546
274	Phosphorylation	CGKSFRRSSSLLQHQ CCCCCCCCHHHHHCC	21.74	28555341
275	Phosphorylation	GKSFRRSSSLLQHQR CCCCCCCHHHHHCCC	24.16	28555341
285	Ubiquitination	LQHQRVHTRERPYEC HHCCCCCCCCCCCCC	31.22	21890473
285	Ubiquitination	LQHQRVHTRERPYEC HHCCCCCCCCCCCCC	31.22	21890473
298	Phosphorylation	ECSECGKSFSLRSNL CCCCCCCCEECCCCC	12.83	24719451
300	Phosphorylation	SECGKSFSLRSNLIH CCCCCCEECCCCCCC	29.93	24719451
313	Phosphorylation	IHHQRVHTGERHECG CCCCCCCCCCCCCCC	37.57	-
319	Ubiquitination	HTGERHECGQCGKSF CCCCCCCCCCCCCCC	3.59	21890473
325	Phosphorylation	ECGQCGKSFSRKSSL CCCCCCCCCCCCCEE	17.46	17081983
327	Phosphorylation	GQCGKSFSRKSSLII CCCCCCCCCCCEEEE	45.98	17081983
330	Phosphorylation	GKSFSRKSSLIIHLR CCCCCCCCEEEEEEE	29.30	28555341
331	Phosphorylation	KSFSRKSSLIIHLRV CCCCCCCEEEEEEEE	26.99	28555341
340	Phosphorylation	IIHLRVHTGERPYEC EEEEEEECCCCCEEC	37.57	25159151
348	Phosphorylation	GERPYECSDCGKSFA CCCCEECCCCCCCHH	24.81	28348404
359	Phosphorylation	KSFAENSSLIKHLRV CCHHHCCHHHCEEEE	45.77	24719451
362	Sumoylation	AENSSLIKHLRVHTG HHCCHHHCEEEECCC	41.71	-
362	Ubiquitination	AENSSLIKHLRVHTG HHCCHHHCEEEECCC	41.71	21890473
362	Sumoylation	AENSSLIKHLRVHTG HHCCHHHCEEEECCC	41.71	-
368	Phosphorylation	IKHLRVHTGERPYEC HCEEEECCCCCCEEE	37.57	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN586_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN586_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN586_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IFN17_HUMAN	IFNA17	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.