ZN543_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN543_HUMAN
• UniProt AC: Q08ER8
• Protein Name: Zinc finger protein 543
• Gene Name: ZNF543
• Organism: Homo sapiens (Human).
• Sequence Length: 600
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MAASAQVSVTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGLLMSLGCPLFKPELIYQLDHRQELWMATKDLSQSSYPGDNTKPKTTEPTFSHLALPEEVLLQEQLTQGASKNSQLGQSKDQDGPSEMQEVHLKIGIGPQRGKLLEKMSSERDGLGSDDGVCTKITQKQVSTEGDLYECDSHGPVTDALIREEKNSYKCEECGKVFKKNALLVQHERIHTQVKPYECTECGKTFSKSTHLLQHLIIHTGEKPYKCMECGKAFNRRSHLTRHQRIHSGEKPYKCSECGKAFTHRSTFVLHHRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHTGEKPYECIECGKAFNRRSYLTWHQQIHTGVKPFECNECGKAFCESADLIQHYIIHTGEKPYKCMECGKAFNRRSHLKQHQRIHTGEKPYECSECGKAFTHCSTFVLHKRTHTGEKPYECKECGKAFSDRADLIRHFSIHTGEKPYECVECGKAFNRSSHLTRHQQIHTGEKPYECIQCGKAFCRSANLIRHSIIHTGEKPYECSECGKAFNRGSSLTHHQRIHTGRNPTIVTDVGRPFMTAQTSVNIQELLLGKEFLNITTEENLW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Ubiquitination	QELWMATKDLSQSSY HHHHHHCCCCHHCCC	47.32	-
77	Phosphorylation	ATKDLSQSSYPGDNT HCCCCHHCCCCCCCC	28.59	-
85	Ubiquitination	SYPGDNTKPKTTEPT CCCCCCCCCCCCCCC	51.26	22505724
122	Ubiquitination	NSQLGQSKDQDGPSE CCCCCCCCCCCCCHH	52.07	-
165	Phosphorylation	GSDDGVCTKITQKQV CCCCCCCHHEEECCC	24.07	-
166	Ubiquitination	SDDGVCTKITQKQVS CCCCCCHHEEECCCC	38.33	29967540
168	Phosphorylation	DGVCTKITQKQVSTE CCCCHHEEECCCCCC	31.13	-
170	Ubiquitination	VCTKITQKQVSTEGD CCHHEEECCCCCCCC	43.98	29967540
200	Sumoylation	REEKNSYKCEECGKV HHHHHCCCHHHHHHE	34.68	-
200	Sumoylation	REEKNSYKCEECGKV HHHHHCCCHHHHHHE	34.68	-
210	Ubiquitination	ECGKVFKKNALLVQH HHHHEEHHCEEEEEC	35.67	29967540
210	Sumoylation	ECGKVFKKNALLVQH HHHHEEHHCEEEEEC	35.67	-
210	Sumoylation	ECGKVFKKNALLVQH HHHHEEHHCEEEEEC	35.67	-
225	Ubiquitination	ERIHTQVKPYECTEC CCCCCCCCCEECCCC	31.87	-
234	Ubiquitination	YECTECGKTFSKSTH EECCCCCCCCCHHHH	59.04	-
250	Phosphorylation	LQHLIIHTGEKPYKC HHHHHHHCCCCCEEE	36.31	29496963
253	Ubiquitination	LIIHTGEKPYKCMEC HHHHCCCCCEEEHHC	55.80	-
278	Phosphorylation	TRHQRIHSGEKPYKC CCCCHHCCCCCCEEC	46.40	29496963
283	Phosphorylation	IHSGEKPYKCSECGK HCCCCCCEECCCCCC	35.38	22817900
286	Phosphorylation	GEKPYKCSECGKAFT CCCCEECCCCCCEEE	31.59	-
290	Acetylation	YKCSECGKAFTHRST EECCCCCCEEECCCE	52.57	7665163
293	Phosphorylation	SECGKAFTHRSTFVL CCCCCEEECCCEEEE	22.65	22817900
306	Phosphorylation	VLHHRSHTGEKPFVC EEECCCCCCCCCEEE	48.56	-
309	Ubiquitination	HRSHTGEKPFVCKEC CCCCCCCCCEEECCC	45.13	-
309	Sumoylation	HRSHTGEKPFVCKEC CCCCCCCCCEEECCC	45.13	-
309	Sumoylation	HRSHTGEKPFVCKEC CCCCCCCCCEEECCC	45.13	-
314	Ubiquitination	GEKPFVCKECGKAFR CCCCEEECCCHHHHH	51.22	-
334	Phosphorylation	IRHYIIHTGEKPYEC EEEEEEECCCCCEEE	36.31	27251275
337	Ubiquitination	YIIHTGEKPYECIEC EEEECCCCCEEEEEC	55.00	-
365	Ubiquitination	QQIHTGVKPFECNEC HHCCCCCCCEECCCH	45.38	-
390	Phosphorylation	IQHYIIHTGEKPYKC HHHHHCCCCCCCEEE	36.31	29496963
393	Ubiquitination	YIIHTGEKPYKCMEC HHCCCCCCCEEEHHH	55.80	-
408	Phosphorylation	GKAFNRRSHLKQHQR HHHHCCHHHHHHHCC	29.90	28258704
418	Phosphorylation	KQHQRIHTGEKPYEC HHHCCCCCCCCCEEC	44.67	29496963
423	Phosphorylation	IHTGEKPYECSECGK CCCCCCCEECCCCHH	40.41	-
426	Phosphorylation	GEKPYECSECGKAFT CCCCEECCCCHHHHH	24.79	28258704
444	Phosphorylation	TFVLHKRTHTGEKPY EEEEECCCCCCCCCC	28.70	29396449
446	Phosphorylation	VLHKRTHTGEKPYEC EEECCCCCCCCCCCC	46.56	29496963
449	Ubiquitination	KRTHTGEKPYECKEC CCCCCCCCCCCCCHH	55.00	-
454	Ubiquitination	GEKPYECKECGKAFS CCCCCCCCHHHHHHH	44.06	-
454	Sumoylation	GEKPYECKECGKAFS CCCCCCCCHHHHHHH	44.06	-
454	Sumoylation	GEKPYECKECGKAFS CCCCCCCCHHHHHHH	44.06	-
471	Phosphorylation	ADLIRHFSIHTGEKP HHHHHHHCCCCCCCC	13.82	28555341
474	Phosphorylation	IRHFSIHTGEKPYEC HHHHCCCCCCCCEEE	45.42	28152594
477	Ubiquitination	FSIHTGEKPYECVEC HCCCCCCCCEEEEEC	55.00	22505724
479	Phosphorylation	IHTGEKPYECVECGK CCCCCCCEEEEECCC	32.78	28152594
486	Sumoylation	YECVECGKAFNRSSH EEEEECCCCCCCCCC	62.56	-
486	Sumoylation	YECVECGKAFNRSSH EEEEECCCCCCCCCC	62.56	-
486	Ubiquitination	YECVECGKAFNRSSH EEEEECCCCCCCCCC	62.56	-
502	Phosphorylation	TRHQQIHTGEKPYEC HHCCCCCCCCCCCHH	48.98	29214152
505	Ubiquitination	QQIHTGEKPYECIQC CCCCCCCCCCHHHHC	55.00	-
514	Ubiquitination	YECIQCGKAFCRSAN CHHHHCCHHHHHHHC	46.01	-
530	Phosphorylation	IRHSIIHTGEKPYEC HHCCCEECCCCCEEC	36.31	29496963
533	Ubiquitination	SIIHTGEKPYECSEC CCEECCCCCEECCHH	55.00	-
535	Phosphorylation	IHTGEKPYECSECGK EECCCCCEECCHHHC	40.41	-
538	Phosphorylation	GEKPYECSECGKAFN CCCCEECCHHHCCCC	24.79	27251275
542	Sumoylation	YECSECGKAFNRGSS EECCHHHCCCCCCCC	62.56	-
542	Sumoylation	YECSECGKAFNRGSS EECCHHHCCCCCCCC	62.56	-
542	Ubiquitination	YECSECGKAFNRGSS EECCHHHCCCCCCCC	62.56	22505724
549	Phosphorylation	KAFNRGSSLTHHQRI CCCCCCCCCCCCCHH	39.86	30257219
563	Phosphorylation	IHTGRNPTIVTDVGR HCCCCCCEEEECCCC	31.46	-
574	Phosphorylation	DVGRPFMTAQTSVNI CCCCCCCCCCCCCCH	18.92	-
578	Phosphorylation	PFMTAQTSVNIQELL CCCCCCCCCCHHHHH	10.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN543_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN543_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN543_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR107_HUMAN	KRTAP10-7	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.