ZN419_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN419_HUMAN
• UniProt AC: Q96HQ0
• Protein Name: Zinc finger protein 419
• Gene Name: ZNF419
• Organism: Homo sapiens (Human).
• Sequence Length: 510
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MAAAALRDPAQVPVAADLLTDHEEGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASLGLASSKTHEITQLESWEEPFMPAWEVVTSAIPRGCWHGAEAEEAPEQIASVGLLSSNIQQHQKQHCGEKPLKRQEGRVPVLRSCKVHLSEKSLQSREVGKALLISSGVLKHQVTHTGEKSHRSSKSREAFHAGKRHYKCSECGKAFGQKYLLVQHQRLHAGKKTYECSECGKLFRDMSNLFIHQIVHTGERPYGCSNCGKSFSRNAHLIEHQRVHTGEKPFTCSECGKAFRHNSTLVQHHKIHTGVRPYECSECGKLFSFNSSLMKHQRIHTGERPYKCSECGKFYSHKSNLIKHWRVHTGERPYKCSDCGKFFTQCSSLMQHQKVHTGEKPFKCNECGRFFRENSTLVRHQRVHTGAKPYECRECGKFFSQSSTLMQHRKVHIGEKPFKCNECGRLFRENSSLVKHQRVHTGAKPYECRECGKFFRHNSSLFKHRRIHTGEMQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Ubiquitination	SKTHEITQLESWEEP CCCEECHHCCCCCCC	49.22	21890473
95	Phosphorylation	PAWEVVTSAIPRGCW CHHHHHHHHCCCCCC	16.76	24719451
120	Ubiquitination	QIASVGLLSSNIQQH HHHHHHHHHHHHHHH	4.31	21890473
120	Ubiquitination	QIASVGLLSSNIQQH HHHHHHHHHHHHHHH	4.31	21890473
121	Ubiquitination	IASVGLLSSNIQQHQ HHHHHHHHHHHHHHH	26.78	21890473
122	Ubiquitination	ASVGLLSSNIQQHQK HHHHHHHHHHHHHHH	37.61	22817900
127	Ubiquitination	LSSNIQQHQKQHCGE HHHHHHHHHHHHCCC	22.04	21890473
133	Ubiquitination	QHQKQHCGEKPLKRQ HHHHHHCCCCCCCCC	43.78	21890473
134 (in isoform 2)	Ubiquitination	-	57.82	21890473
134	Ubiquitination	HQKQHCGEKPLKRQE HHHHHCCCCCCCCCC	57.82	21890473
151	Ubiquitination	VPVLRSCKVHLSEKS CCCHHHCEEECCHHH	33.66	-
153	Ubiquitination	VLRSCKVHLSEKSLQ CHHHCEEECCHHHHC	14.77	21890473
153	Ubiquitination	VLRSCKVHLSEKSLQ CHHHCEEECCHHHHC	14.77	21890473
154	Ubiquitination	LRSCKVHLSEKSLQS HHHCEEECCHHHHCC	8.72	21890473
154	Ubiquitination	LRSCKVHLSEKSLQS HHHCEEECCHHHHCC	8.72	21890473
157	Ubiquitination	CKVHLSEKSLQSREV CEEECCHHHHCCHHH	53.76	-
164	Ubiquitination	KSLQSREVGKALLIS HHHCCHHHHHHHHHH	10.41	22817900
165	Ubiquitination	SLQSREVGKALLISS HHCCHHHHHHHHHHH	12.55	22817900
166 (in isoform 1)	Ubiquitination	-	40.82	21890473
166	Ubiquitination	LQSREVGKALLISSG HCCHHHHHHHHHHHC	40.82	21890473
166	Sumoylation	LQSREVGKALLISSG HCCHHHHHHHHHHHC	40.82	28112733
166	Sumoylation	LQSREVGKALLISSG HCCHHHHHHHHHHHC	40.82	-
167	Ubiquitination	QSREVGKALLISSGV CCHHHHHHHHHHHCC	11.15	21890473
169	Ubiquitination	REVGKALLISSGVLK HHHHHHHHHHHCCCE	4.22	21890473
169	Ubiquitination	REVGKALLISSGVLK HHHHHHHHHHHCCCE	4.22	21890473
170	Ubiquitination	EVGKALLISSGVLKH HHHHHHHHHHCCCEE	2.99	21890473
171	Phosphorylation	VGKALLISSGVLKHQ HHHHHHHHHCCCEEE	22.47	26852163
172	Phosphorylation	GKALLISSGVLKHQV HHHHHHHHCCCEEEE	26.40	26852163
176	Sumoylation	LISSGVLKHQVTHTG HHHHCCCEEEEECCC	29.59	28112733
177	Ubiquitination	ISSGVLKHQVTHTGE HHHCCCEEEEECCCC	24.15	22817900
178	Ubiquitination	SSGVLKHQVTHTGEK HHCCCEEEEECCCCC	39.97	22817900
182	Ubiquitination	LKHQVTHTGEKSHRS CEEEEECCCCCCCCC	37.36	21890473
183 (in isoform 2)	Ubiquitination	-	32.50	21890473
183	Ubiquitination	KHQVTHTGEKSHRSS EEEEECCCCCCCCCH	32.50	21890473
186	Phosphorylation	VTHTGEKSHRSSKSR EECCCCCCCCCHHHH	21.60	-
189	Phosphorylation	TGEKSHRSSKSREAF CCCCCCCCHHHHHHH	36.37	-
192	Phosphorylation	KSHRSSKSREAFHAG CCCCCHHHHHHHHCC	36.98	-
197	Ubiquitination	SKSREAFHAGKRHYK HHHHHHHHCCCCCEE	40.39	22817900
198	Ubiquitination	KSREAFHAGKRHYKC HHHHHHHCCCCCEEH	20.81	22817900
202	Ubiquitination	AFHAGKRHYKCSECG HHHCCCCCEEHHHHH	29.86	21890473
202	Ubiquitination	AFHAGKRHYKCSECG HHHCCCCCEEHHHHH	29.86	21890473
203	Ubiquitination	FHAGKRHYKCSECGK HHCCCCCEEHHHHHH	20.09	21890473
203	Ubiquitination	FHAGKRHYKCSECGK HHCCCCCEEHHHHHH	20.09	21890473
210	Ubiquitination	YKCSECGKAFGQKYL EEHHHHHHHHHCEEE	52.80	22817900
211	Ubiquitination	KCSECGKAFGQKYLL EHHHHHHHHHCEEEE	10.09	22817900
215 (in isoform 1)	Ubiquitination	-	37.94	21890473
215	Sumoylation	CGKAFGQKYLLVQHQ HHHHHHCEEEEEECC	37.94	-
215	Ubiquitination	CGKAFGQKYLLVQHQ HHHHHHCEEEEEECC	37.94	21890473
215	Sumoylation	CGKAFGQKYLLVQHQ HHHHHHCEEEEEECC	37.94	-
216	Ubiquitination	GKAFGQKYLLVQHQR HHHHHCEEEEEECCC	9.44	21890473
244	Ubiquitination	GKLFRDMSNLFIHQI HHHHHHHHHHHHEEH	34.37	21890473
244	Phosphorylation	GKLFRDMSNLFIHQI HHHHHHHHHHHHEEH	34.37	25262027
254	Phosphorylation	FIHQIVHTGERPYGC HHEEHHHCCCCCCCC	29.82	25262027
267	Ubiquitination	GCSNCGKSFSRNAHL CCCCCCCCCCCCCEE	17.46	29967540
269	Phosphorylation	SNCGKSFSRNAHLIE CCCCCCCCCCCEEEE	31.54	17081983
282	Phosphorylation	IEHQRVHTGEKPFTC EECCCCCCCCCCEEH	44.15	-
286	Ubiquitination	RVHTGEKPFTCSECG CCCCCCCCEEHHHHH	26.02	21890473
286	Ubiquitination	RVHTGEKPFTCSECG CCCCCCCCEEHHHHH	26.02	21890473
287	Ubiquitination	VHTGEKPFTCSECGK CCCCCCCEEHHHHHH	18.64	21890473
299	Ubiquitination	CGKAFRHNSTLVQHH HHHHHCCCCCEEECC	32.22	21890473
300 (in isoform 2)	Ubiquitination	-	19.59	21890473
300	Ubiquitination	GKAFRHNSTLVQHHK HHHHCCCCCEEECCE	19.59	21890473
309	Ubiquitination	LVQHHKIHTGVRPYE EEECCEECCCCCCEE	22.75	29967540
310	Ubiquitination	VQHHKIHTGVRPYEC EECCEECCCCCCEEC	40.62	29967540
310	Phosphorylation	VQHHKIHTGVRPYEC EECCEECCCCCCEEC	40.62	28555341
319	Ubiquitination	VRPYECSECGKLFSF CCCEECCCCCCEEEC	59.97	21890473
319	Ubiquitination	VRPYECSECGKLFSF CCCEECCCCCCEEEC	59.97	21890473
320	Ubiquitination	RPYECSECGKLFSFN CCEECCCCCCEEECC	3.15	21890473
320	Ubiquitination	RPYECSECGKLFSFN CCEECCCCCCEEECC	3.15	21890473
322	Ubiquitination	YECSECGKLFSFNSS EECCCCCCEEECCHH	59.00	29967540
323	Ubiquitination	ECSECGKLFSFNSSL ECCCCCCEEECCHHH	2.36	29967540
329	Phosphorylation	KLFSFNSSLMKHQRI CEEECCHHHHCCCCC	33.32	24719451
330 (in isoform 5)	Phosphorylation	-	5.49	24719451
332 (in isoform 1)	Ubiquitination	-	41.71	21890473
332	Ubiquitination	SFNSSLMKHQRIHTG ECCHHHHCCCCCCCC	41.71	21890473
333	Ubiquitination	FNSSLMKHQRIHTGE CCHHHHCCCCCCCCC	14.26	21890473
338	Phosphorylation	MKHQRIHTGERPYKC HCCCCCCCCCCCEEC	38.06	27251275
339 (in isoform 5)	Phosphorylation	-	18.11	24719451
342	Ubiquitination	RIHTGERPYKCSECG CCCCCCCCEECCCCC	28.74	29967540
343	Ubiquitination	IHTGERPYKCSECGK CCCCCCCEECCCCCC	30.74	29967540
355	Ubiquitination	CGKFYSHKSNLIKHW CCCEECCCCCCCCCE	34.79	29967540
356	Ubiquitination	GKFYSHKSNLIKHWR CCEECCCCCCCCCEE	31.29	29967540
366	Phosphorylation	IKHWRVHTGERPYKC CCCEEEECCCCCEEC	37.57	27251275
394	Phosphorylation	MQHQKVHTGEKPFKC HHCCCCCCCCCCCCC	50.45	23898821
412	Phosphorylation	GRFFRENSTLVRHQR HHHHCCCCCCEEEEE	20.54	28555341
413	Phosphorylation	RFFRENSTLVRHQRV HHHCCCCCCEEEEEE	40.63	29083192
437	Phosphorylation	RECGKFFSQSSTLMQ HHHHCCCCCCCHHHH	32.08	28450419
439	Phosphorylation	CGKFFSQSSTLMQHR HHCCCCCCCHHHHCC	24.88	28450419
440	Phosphorylation	GKFFSQSSTLMQHRK HCCCCCCCHHHHCCC	20.23	28450419
441	Phosphorylation	KFFSQSSTLMQHRKV CCCCCCCHHHHCCCE	31.34	28450419
490	Ubiquitination	YECRECGKFFRHNSS CCHHHCCCHHCCCCH	53.65	-
497	Phosphorylation	KFFRHNSSLFKHRRI CHHCCCCHHHCCCCC	43.04	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN419_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN419_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN419_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR107_HUMAN	KRTAP10-7	physical	25416956
TRI39_HUMAN	TRIM39	physical	26186194
TRI39_HUMAN	TRIM39	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.